Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods
about
Virtual screening for potential inhibitors of Mcl-1 conformations sampled by normal modes, molecular dynamics, and nuclear magnetic resonance.Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.Killing Two Cells with One Stone: Pharmacologic BCL-2 Family Targeting for Cancer Cell Death and Immune Modulation.Synthesis, Fungicidal Activity, and Structure Activity Relationship of β-Acylaminocycloalkylsulfonamides against Botrytis cinerea.Solution NMR Spectroscopy in Target-Based Drug Discovery.Protein-protein interaction inhibitors: advances in anticancer drug design.Latest Advances Towards Ras Inhibition: A Medicinal Chemistry Perspective.Mcl-1 inhibitors: a patent review.N-acylsulfonamides: Synthetic routes and biological potential in medicinal chemistry.Selective Covalent Targeting of Anti-Apoptotic BFL-1 by Cysteine-Reactive Stapled Peptide Inhibitors.Peptide-Directed Binding for the Discovery of Modulators of α-Helix-Mediated Protein-Protein Interactions: Proof-of-Concept Studies with the Apoptosis Regulator Mcl-1.Allosteric sensitization of proapoptotic BAX.Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells.Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors.Substituted indole Mcl-1 inhibitors: a patent evaluation (WO2015148854A1).Carboxylate isosteres for caspase inhibitors: the acylsulfonamide case revisited.In silico approaches to identify novel myeloid cell leukemia-1 (Mcl-1) inhibitors for treatment of cancer.PTBP1 enhances miR-101-guided AGO2 targeting to MCL1 and promotes miR-101-induced apoptosis.Discovery of Mcl-1 inhibitors from integrated high throughput and virtual screeningMCL-1 inhibition in cancer treatment
P2860
Q33834795-57338042-41A3-445F-BC85-4EB5CF93014DQ36280596-DBA9BD84-23D2-41D1-BB8D-ED0B7C259944Q37521403-E1D4FAC4-4C3A-4C3B-A245-29253263C4F2Q37630503-C0CA36FA-AFB3-42CB-9DA3-F477FEBE28C6Q38612644-10C9A388-AD99-4816-9DEB-092A1F6A3017Q38935390-21883F87-1D92-456F-8A4E-B5684DA2510EQ38956084-590607E2-A2AD-41D3-9827-FEDE2E8E9984Q38981785-C44D363D-9EC5-465B-8620-79F7678709EEQ39386218-65845440-4AF6-4360-AE7C-2067EAD8CA64Q41374031-F152A406-315B-491C-925D-675144D66F52Q41569041-11EBC856-F7E3-4260-B99D-4201E83A065EQ49261983-7BC805EB-ADCB-430A-858F-7B7A795CC033Q51136478-7C8E3837-114F-491F-85B2-A660422D2218Q51308516-D846F2B9-C5FE-4CA9-A37E-62644EE340D7Q51456092-93DD5DBE-D0DF-475B-BA8B-AD279E9652DFQ53098063-6513ED41-5781-4FA1-A83C-3425E485571BQ53159453-EE8E6BE2-DB0F-45B0-B909-EC68FC96A27DQ55129497-E50C67E6-E68A-4673-B790-E9CB29514EA5Q56811078-9ECB7913-2359-4C65-99A8-6AF56274057DQ58694408-819B147A-8F77-41C6-838B-31D7AD72D3AE
P2860
Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods
description
2016 nî lūn-bûn
@nan
2016 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Discovery of 2-Indole-acylsulf ...... s Using Fragment-Based Methods
@ast
Discovery of 2-Indole-acylsulf ...... s Using Fragment-Based Methods
@en
Discovery of 2-Indole-acylsulf ...... s Using Fragment-Based Methods
@nl
type
label
Discovery of 2-Indole-acylsulf ...... s Using Fragment-Based Methods
@ast
Discovery of 2-Indole-acylsulf ...... s Using Fragment-Based Methods
@en
Discovery of 2-Indole-acylsulf ...... s Using Fragment-Based Methods
@nl
prefLabel
Discovery of 2-Indole-acylsulf ...... s Using Fragment-Based Methods
@ast
Discovery of 2-Indole-acylsulf ...... s Using Fragment-Based Methods
@en
Discovery of 2-Indole-acylsulf ...... s Using Fragment-Based Methods
@nl
P2093
P2860
P1476
Discovery of 2-Indole-acylsulf ...... s Using Fragment-Based Methods
@en
P2093
Allison L Arnold
Anders Friberg
Claire Gregg
Craig M Goodwin
DeMarco V Camper
Edward T Olejniczak
James C Tarr
Johannes Belmar
John L Sensintaffar
P2860
P304
P356
10.1021/ACS.JMEDCHEM.5B01660
P407
P577
2016-02-15T00:00:00Z