Selective Covalent Targeting of Anti-Apoptotic BFL-1 by Cysteine-Reactive Stapled Peptide Inhibitors.
about
Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1A New Methodology for Incorporating Chiral Linkers into Stapled Peptides.Killing Two Cells with One Stone: Pharmacologic BCL-2 Family Targeting for Cancer Cell Death and Immune Modulation.hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents.Close encounter of the covalent kind: Inhibiting MCL1's proapoptotic activity with covalent inhibitors.Crystal Structures of Anti-apoptotic BFL-1 and Its Complex with a Covalent Stapled Peptide Inhibitor.Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design.Helenalin Analogues Targeting NF-κB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles.Enhanced Permeability and Binding Activity of Isobutylene-Grafted Peptides.Allosteric sensitization of proapoptotic BAX.Exploiting the pro-apoptotic function of NOXA as a therapeutic modality in cancer.
P2860
Q33779035-4EFC8950-F42D-4B48-A9C5-FCE3A1832451Q36339600-14207A8D-62FB-4C39-B1F5-B8963C0CC899Q37521403-C314E84B-93A3-4659-84FD-5A17A41C576FQ37657934-690DD7D7-79ED-4C5B-817A-C65F90FBC496Q42328732-EB4E5E0E-10C6-4C81-B6C0-8D4DB36F30FCQ47257058-49A0F245-A14B-4369-A770-32E2C7EFD6A5Q47942361-1C83AFA4-E44C-425B-A0C2-F869AD21D743Q48211122-A4A5FF22-8371-4F9F-82EB-057B2CC29360Q48362157-158A894D-AC19-4CD3-8FF1-2B32226DB777Q49261983-BAAB1CA6-7850-4DA6-A7E9-3DDD9FCB7943Q50911306-4D0092A4-7685-41CC-88BC-20900FC884C8
P2860
Selective Covalent Targeting of Anti-Apoptotic BFL-1 by Cysteine-Reactive Stapled Peptide Inhibitors.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Selective Covalent Targeting o ...... ve Stapled Peptide Inhibitors.
@en
type
label
Selective Covalent Targeting o ...... ve Stapled Peptide Inhibitors.
@en
prefLabel
Selective Covalent Targeting o ...... ve Stapled Peptide Inhibitors.
@en
P2093
P2860
P1476
Selective Covalent Targeting o ...... ive Stapled Peptide Inhibitors
@en
P2093
Gregory H Bird
Loren D Walensky
Rachel M Guerra
P2860
P304
P356
10.1016/J.CHEMBIOL.2016.07.022
P577
2016-09-08T00:00:00Z