Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis

Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis

Item
http://www.wikidata.org/entity/Q27704217
Synthesis and biological evaluation of novel imidazolidine derivatives as candidates to schistosomicidal agents.Comparative effects of histone deacetylases inhibitors and resveratrol on Trypanosoma cruzi replication, differentiation, infectivity and gene expression.Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth.Targeting histone deacetylase 8 as a therapeutic approach to cancer and neurodegenerative diseases.Structure of 'linkerless' hydroxamic acid inhibitor-HDAC8 complex confirms the formation of an isoform-specific subpocketThe Schistosoma mansoni genome encodes thousands of long non-coding RNAs predicted to be functional at different parasite life-cycle stages.Structure-activity relationships of hydroxamate-based histone deacetylase-8 inhibitors: reality behind anticancer drug discovery.Analysis of the interactome of Schistosoma mansoni histone deacetylase 8.Structure-Activity Relationship of Propargylamine-Based HDAC Inhibitors.Isophthalic Acid-Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni.Design, Synthesis, and Evaluation of Novel Tyrosine-Based DNA Gyrase B Inhibitors.Design, Synthesis, and Biological Evaluation of Tetrahydroisoquinoline-Based Histone Deacetylase 8 Selective Inhibitors.Photochromic histone deacetylase inhibitors based on dithienylethenes and fulgimides.Compounds from African Medicinal Plants with Activities Against Selected Parasitic Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis.Innovation in neglected tropical disease drug discovery and development.Histone deacetylases as targets for antitrypanosomal drugs
P2860

Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis

Item
http://www.wikidata.org/entity/Q27704217
description
2016 nî lūn-bûn
@nan
2016 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի մարտին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Structure-Based Design and Syn ...... e Treatment of Schistosomiasis
@ast
Structure-Based Design and Syn ...... e Treatment of Schistosomiasis
@en
Structure-Based Design and Syn ...... e Treatment of Schistosomiasis
@nl
type
label
Structure-Based Design and Syn ...... e Treatment of Schistosomiasis
@ast
Structure-Based Design and Syn ...... e Treatment of Schistosomiasis
@en
Structure-Based Design and Syn ...... e Treatment of Schistosomiasis
@nl
prefLabel
Structure-Based Design and Syn ...... e Treatment of Schistosomiasis
@ast
Structure-Based Design and Syn ...... e Treatment of Schistosomiasis
@en
Structure-Based Design and Syn ...... e Treatment of Schistosomiasis
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P921
P356
P1433
P1476
Structure-Based Design and Syn ...... e Treatment of Schistosomiasis
@en
P2093
P304
P31
P356
10.1021/ACS.JMEDCHEM.5B01478
P407
P433
P478
P50
P577
P5875
P698
P921