about
The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD fingerSequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitinationHuman TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 familyANP32E is a histone chaperone that removes H2A.Z from chromatinThe structural plasticity of SCA7 domains defines their differential nucleosome-binding propertiesThe human TFIID components TAF(II)135 and TAF(II)20 and the yeast SAGA components ADA1 and TAF(II)68 heterodimerize to form histone-like pairsCrystal structure, biochemical and genetic characterization of yeast and E. cuniculi TAF(II)5 N-terminal domain: implications for TFIID assemblyNoncanonical Tandem SH2 Enables Interaction of Elongation Factor Spt6 with RNA Polymerase IIThe structure of an Iws1/Spt6 complex reveals an interaction domain conserved in TFIIS, Elongin A and Med26Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoniCharacterization of the interaction between protein Snu13p/15.5K and the Rsa1p/NUFIP factor and demonstration of its functional importance for snoRNP assemblyTFIID TAF6-TAF9 Complex Formation Involves the HEAT Repeat-containing C-terminal Domain of TAF6 and Is Modulated by TAF5 ProteinMolecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoniStructure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of SchistosomiasisMolecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1Mutagenesis and crystallographic studies of Zymomonas mobilis tRNA-guanine transglycosylase reveal aspartate 102 as the active site nucleophileFunctional analysis of the TFIID-specific yeast TAF4 (yTAF(II)48) reveals an unexpected organization of its histone-fold domainCombattre les maladies négligées en ciblant sélectivement leurs enzymes épigénétiques : le cas de la désacétylase 8 (HDAC8) de Schistosoma mansoni.Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors.Discovery of inhibitors of Schistosoma mansoni HDAC8 by combining homology modeling, virtual screening, and in vitro validation.Strategies for bacterial expression of protein-peptide complexes: application to solubilization of papillomavirus E6Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoniThe histone fold is a key structural motif of transcription factor TFIID.Solution structure of human corticotropin releasing factor by 1H NMR and distance geometry with restrained molecular dynamics.TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups.Baculovirus VP1054 is an acquired cellular PURα, a nucleic acid-binding protein specific for GGN repeats.The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes.Assembly of protein complexes by coexpression in prokaryotic and eukaryotic hosts: an overview.DNA binding by Sgf11 protein affects histone H2B deubiquitination by Spt-Ada-Gcn5-acetyltransferase (SAGA).Robots, pipelines, polyproteins: enabling multiprotein expression in prokaryotic and eukaryotic cells.Expression in Escherichia coli: becoming faster and more complex.Schistosome sirtuins as drug targets.Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives.HDAC8: a multifaceted target for therapeutic interventions.Alkoxyurea-Based Histone Deacetylase Inhibitors Increase Cisplatin Potency in Chemoresistant Cancer Cell Lines.Complex Reconstitution and Characterization by Combining Co-expression Techniques in Escherichia coli with High-Throughput.Histone folds mediate selective heterodimerization of yeast TAF(II)25 with TFIID components yTAF(II)47 and yTAF(II)65 and with SAGA component ySPT7.Large-Scale Overproduction and Purification of Recombinant Histone Deacetylase 8 (HDAC8) from the Human-Pathogenic Flatworm Schistosoma mansoni.Homology modeling of parasite histone deacetylases to guide the structure-based design of selective inhibitors.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Christophe Romier
@ast
Christophe Romier
@en
Christophe Romier
@es
Christophe Romier
@nl
Christophe Romier
@sl
type
label
Christophe Romier
@ast
Christophe Romier
@en
Christophe Romier
@es
Christophe Romier
@nl
Christophe Romier
@sl
prefLabel
Christophe Romier
@ast
Christophe Romier
@en
Christophe Romier
@es
Christophe Romier
@nl
Christophe Romier
@sl
P106
P21
P31
P496
0000-0002-3680-935X