Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery

Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery

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Fragment Screening of RORγt Using Cocktail Crystallography: Identification of Simultaneous Binding of Multiple Fragments Zinc oxide nanoparticles exhibit cytotoxicity and genotoxicity through oxidative stress responses in human lung fibroblasts and Drosophila melanogaster Twenty years on: the impact of fragments on drug discovery.A Computational Investigation of Small-Molecule Engagement of Hot Spots at Protein-Protein Interaction Interfaces.The role of modulation of antioxidant enzyme systems in the treatment of neurodegenerative diseases.Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Differential regulation of innate immune cytokine production through pharmacological activation of Nuclear Factor-Erythroid-2-Related Factor 2 (NRF2) in burn patient immune cells and monocytes.Polar Recognition Group Study of Keap1-Nrf2 Protein-Protein Interaction Inhibitors Hot-spot identification on a broad class of proteins and RNA suggest unifying principles of molecular recognition.Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition Identification of novel Nrf2 activators from Cinnamomum chartophyllum H.W. Li and their potential application of preventing oxidative insults in human lung epithelial cells Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer Effects of Novel Nitric Oxide-Releasing Molecules against Oxidative Stress on Retinal Pigmented Epithelial Cells.WD40 repeat domain proteins: a novel target class?Mimicking Intermolecular Interactions of Tight Protein-Protein Complexes for Small-Molecule Antagonists.Stress-sensing mechanisms and the physiological roles of the Keap1-Nrf2 system during cellular stress.Identification of a novel small-molecule Keap1-Nrf2 PPI inhibitor with cytoprotective effects on LPS-induced cardiomyopathy.Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a review

P2860

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P2860

Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery

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