Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor
about
The impact of structural biology in medicine illustrated with four case studies.Role of SHP2 in hematopoiesis and leukemogenesis.Targeting Tyrosine Phosphatases: Time to End the Stigma.Strategies for monitoring and combating resistance to combination kinase inhibitors for cancer therapy.Chondroitin sulfatases differentially regulate Wnt signaling in prostate stem cells through effects on SHP2, phospho-ERK1/2, and Dickkopf Wnt signaling pathway inhibitor (DKK3).Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases.Interrogating Protein Phosphatases with Chemical Activity Probes.New Approaches to Difficult Drug Targets: The Phosphatase StoryStructural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibitionMechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2
P2860
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P2860
Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor
description
2016 nî lūn-bûn
@nan
2016 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年学术文章
@wuu
2016年学术文章
@zh-cn
2016年学术文章
@zh-hans
2016年学术文章
@zh-my
2016年学术文章
@zh-sg
2016年學術文章
@yue
name
Allosteric Inhibition of SHP2: ...... icacious Phosphatase Inhibitor
@ast
Allosteric Inhibition of SHP2: ...... icacious Phosphatase Inhibitor
@en
Allosteric Inhibition of SHP2: ...... icacious Phosphatase Inhibitor
@nl
type
label
Allosteric Inhibition of SHP2: ...... icacious Phosphatase Inhibitor
@ast
Allosteric Inhibition of SHP2: ...... icacious Phosphatase Inhibitor
@en
Allosteric Inhibition of SHP2: ...... icacious Phosphatase Inhibitor
@nl
prefLabel
Allosteric Inhibition of SHP2: ...... icacious Phosphatase Inhibitor
@ast
Allosteric Inhibition of SHP2: ...... icacious Phosphatase Inhibitor
@en
Allosteric Inhibition of SHP2: ...... icacious Phosphatase Inhibitor
@nl
P2093
P1476
Allosteric Inhibition of SHP2: ...... icacious Phosphatase Inhibitor
@en
P2093
Brant Firestone
Cary Fridrich
Christine Hiu-Tung Chen
Christopher Towler
Denise Grunenfelder
Dyuti Majumdar
Franco Lombardo
Francois Lenoir
Jay Larrow
P304
P356
10.1021/ACS.JMEDCHEM.6B00680
P407
P577
2016-09-08T00:00:00Z