Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations
about
Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties.Pharmacotherapy of relapsed/refractory chronic lymphocytic leukemia.Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Establishing a chemical genetic link between Bruton tyrosine kinase activity in malignant B cells and cell functions involved in the micro-environmental dialogue.Are BTK and PLCG2 mutations necessary and sufficient for ibrutinib resistance in chronic lymphocytic leukemia?First-in-human phase 1 study of the BTK inhibitor GDC-0853 in relapsed or refractory B-cell NHL and CLL.PLCG2 C2 domain mutations co-occur with BTK and PLCG2 resistance mutations in chronic lymphocytic leukemia undergoing ibrutinib treatment.
P2860
Q33786371-C6D987E9-351B-48BE-A6BB-24FDF438032CQ38818283-272FB47C-0830-422B-99B3-1147C01A77D6Q39433250-6AE7B6EC-6760-4AB2-B2EB-A3C52EAE092BQ48338363-93683274-896B-41D0-8E61-12714F7D32FDQ49582344-BEED0950-1A7D-46EF-BF98-A0E9FBDDB708Q52645845-C484C5E5-B506-44C1-8CD8-7321FDB9290FQ53745405-BB995D3A-3C04-478A-9EF2-3C3E6CC25FEF
P2860
Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations
description
2016 nî lūn-bûn
@nan
2016 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Battling Btk Mutants With Nonc ...... me Cys481 and Thr474 Mutations
@ast
Battling Btk Mutants With Nonc ...... me Cys481 and Thr474 Mutations
@en
Battling Btk Mutants With Nonc ...... me Cys481 and Thr474 Mutations
@nl
type
label
Battling Btk Mutants With Nonc ...... me Cys481 and Thr474 Mutations
@ast
Battling Btk Mutants With Nonc ...... me Cys481 and Thr474 Mutations
@en
Battling Btk Mutants With Nonc ...... me Cys481 and Thr474 Mutations
@nl
prefLabel
Battling Btk Mutants With Nonc ...... me Cys481 and Thr474 Mutations
@ast
Battling Btk Mutants With Nonc ...... me Cys481 and Thr474 Mutations
@en
Battling Btk Mutants With Nonc ...... me Cys481 and Thr474 Mutations
@nl
P2093
P1433
P1476
Battling Btk Mutants With Nonc ...... me Cys481 and Thr474 Mutations
@en
P2093
Adam R Johnson
Alberto Estevez
Arna Katewa
Christine Tam
Christine Yu
Daniel F Ortwine
Elicia Penuel
Emily Gogol
James J Crawford
P304
P356
10.1021/ACSCHEMBIO.6B00480
P577
2016-10-21T00:00:00Z