Alanine scanning mutagenesis of the alpha-helix 115-123 of phage T4 lysozyme: effects on structure, stability and the binding of solvent
about
Single, double and quadruple alanine substitutions at oligomeric interfaces identify hydrophobicity as the key determinant of human neutrophil alpha defensin HNP1 functionA helix propensity scale based on experimental studies of peptides and proteinsInteratomic potentials and solvation parameters from protein engineering data for buried residuesPotential use of additivity of mutational effects in simplifying protein engineeringAre the parameters of various stabilization factors estimated from mutant human lysozymes compatible with other proteins?Dynamics of lysozyme structure network: probing the process of unfoldingOccurrence of protein structure elements in conserved sequence regions.Rational optimization of a short human P-selectin-binding peptide leads to nanomolar affinity antagonists.A test of the "jigsaw puzzle" model for protein folding by multiple methionine substitutions within the core of T4 lysozyme.Detecting coevolution without phylogenetic trees? Tree-ignorant metrics of coevolution perform as well as tree-aware metrics.Molecular targets and mechanisms for ethanol action in glycine receptorsPredicting the reactivity of proteins from their sequence alone: Kazal family of protein inhibitors of serine proteinases.Combinatorial mutagenesis to restrict amino acid usage in an enzyme to a reduced setDependence of α-helical and β-sheet amino acid propensities on the overall protein fold type.Molecular determinants of polyubiquitin linkage selection by an HECT ubiquitin ligase.Transmission electron microscopy for the evaluation and optimization of crystal growthA direct comparison of helix propensity in proteins and peptides.Thermal stability of hydrophobic heme pocket variants of oxidized cytochrome cInteraction between water and polar groups of the helix backbone: an important determinant of helix propensitiesElectrostatic interactions in the reconstitution of an SH2 domain from constituent peptide fragments.Tolerance of Arc repressor to multiple-alanine substitutions.Rescue of abasic hammerhead ribozymes by exogenous addition of specific basesPeptide scanning for studying structure-activity relationships in drug discovery.Detection of Asp371, Phe375, and Tyr376 Influence on GD-95-10 Lipase Using Alanine Scanning Mutagenesis.Insertion mutagenesis of the lac repressor and its implications for structure-function analysis.Reengineering granulocyte colony-stimulating factor for enhanced stability.A Role for the 2' OH of peptidyl-tRNA substrate in peptide release on the ribosome revealed through RF-mediated rescue.Molecular and biological constraints on ligand-binding affinity and specificity.Perturbation-response scanning reveals ligand entry-exit mechanisms of ferric binding protein.Alanine-scanning mutagenesis of the beta-sheet region of phage T4 lysozyme suggests that tertiary context has a dominant effect on beta-sheet formation.The response of T4 lysozyme to large-to-small substitutions within the core and its relation to the hydrophobic effect.Mutations in the fourth EGF-like domain affect thrombomodulin-induced changes in the active site of thrombin.Molecular dynamics study of an insertion/duplication mutant of bacteriophage T4 lysozyme reveals the nature of α→β transition in full protein context.
P2860
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P2860
Alanine scanning mutagenesis of the alpha-helix 115-123 of phage T4 lysozyme: effects on structure, stability and the binding of solvent
description
1995 nî lūn-bûn
@nan
1995 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Alanine scanning mutagenesis o ...... ity and the binding of solvent
@ast
Alanine scanning mutagenesis o ...... ity and the binding of solvent
@en
Alanine scanning mutagenesis o ...... ity and the binding of solvent
@nl
type
label
Alanine scanning mutagenesis o ...... ity and the binding of solvent
@ast
Alanine scanning mutagenesis o ...... ity and the binding of solvent
@en
Alanine scanning mutagenesis o ...... ity and the binding of solvent
@nl
prefLabel
Alanine scanning mutagenesis o ...... ity and the binding of solvent
@ast
Alanine scanning mutagenesis o ...... ity and the binding of solvent
@en
Alanine scanning mutagenesis o ...... ity and the binding of solvent
@nl
P2093
P356
P1476
Alanine scanning mutagenesis o ...... ity and the binding of solvent
@en
P2093
P304
P356
10.1006/JMBI.1994.0087
P407
P577
1995-02-17T00:00:00Z