Biological implications of a 3 A structure of dimeric antithrombin
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Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinasesProbing serpin reactive-loop conformations by proteolytic cleavageCrystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism.Heparan sulfate proteoglycans of the cardiovascular system. Specific structures emerge but how is synthesis regulated?Thromboembolic disease due to thermolabile conformational changes of antithrombin Rouen-VI (187 Asn-->Asp)The anticoagulant activation of antithrombin by heparinCrystal structure of monomeric native antithrombin reveals a novel reactive center loop conformationInactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational diseaseImportance of the release of strand 1C to the polymerization mechanism of inhibitory serpinsPepsin-inhibitory activity of the uterine serpinsAn overview of the serpin superfamilyCrystal structure of baculovirus P35: role of a novel reactive site loop in apoptotic caspase inhibitionThe conformational activation of antithrombin. A 2.85-A structure of a fluorescein derivative reveals an electrostatic link between the hinge and heparin binding regionsTopography of a 2.0 Å structure of α1-antitrypsin reveals targets for rational drug design to prevent conformational diseaseThe influence of hinge region residue Glu-381 on antithrombin allostery and metastabilityStructure of native protein C inhibitor provides insight into its multiple functionsC1 inhibitor serpin domain structure reveals the likely mechanism of heparin potentiation and conformational diseaseStructural and Functional Characterization of a Highly Specific Serpin in the Insect Innate ImmunityThree-dimensional structure of a schistosome serpin revealing an unusual configuration of the helical subdomainHigh resolution structure of cleaved Serpin 42 Da from Drosophila melanogasterCrystal structure of an uncleaved alpha 1-antitrypsin reveals the conformation of its inhibitory reactive loopThe molecular interactions of heat shock protein 47 (Hsp47) and their implications for collagen biosynthesisLatent S49P neuroserpin forms polymers in the dementia familial encephalopathy with neuroserpin inclusion bodiesStructure of a serpin-enzyme complex probed by cysteine substitutions and fluorescence spectroscopy.AFM Imaging Reveals Topographic Diversity of Wild Type and Z Variant Polymers of Human α1-Proteinase InhibitorThe critical role of hinge-region expulsion in the induced-fit heparin binding mechanism of antithrombin.Formation of the covalent chymotrypsin.antichymotrypsin complex involves no large-scale movement of the enzyme.Polymerization of plasminogen activator inhibitor-1.From natural to synthetic multisite thrombin inhibitors.A novel anti-angiogenic form of antithrombin with retained proteinase binding ability and heparin affinity.Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence. Evidence for an exosite determinant of factor Xa specificity in heparin-activated antithrombin.Hydration structure of antithrombin conformers and water transfer during reactive loop insertionAllosteric activation of antithrombin critically depends upon hinge region extension.The shapes of Z-α1-antitrypsin polymers in solution support the C-terminal domain-swap mechanism of polymerization.The projection structure of EmrE, a proton-linked multidrug transporter from Escherichia coli, at 7 A resolutionThe necrotic gene in Drosophila corresponds to one of a cluster of three serpin transcripts mapping at 43A1.2.Blocking formation of large protein aggregates by small peptides.A novel mode of polymerization of alpha1-proteinase inhibitor.Energy landscapes of functional proteins are inherently risky.Serpin Inhibition Mechanism: A Delicate Balance between Native Metastable State and Polymerization.
P2860
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P2860
Biological implications of a 3 A structure of dimeric antithrombin
description
1994 nî lūn-bûn
@nan
1994 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Biological implications of a 3 A structure of dimeric antithrombin
@ast
Biological implications of a 3 A structure of dimeric antithrombin
@en
Biological implications of a 3 A structure of dimeric antithrombin
@nl
type
label
Biological implications of a 3 A structure of dimeric antithrombin
@ast
Biological implications of a 3 A structure of dimeric antithrombin
@en
Biological implications of a 3 A structure of dimeric antithrombin
@nl
prefLabel
Biological implications of a 3 A structure of dimeric antithrombin
@ast
Biological implications of a 3 A structure of dimeric antithrombin
@en
Biological implications of a 3 A structure of dimeric antithrombin
@nl
P2093
P3181
P1433
P1476
Biological implications of a 3 A structure of dimeric antithrombin
@en
P2093
P304
P3181
P356
10.1016/S0969-2126(00)00028-9
P577
1994-04-15T00:00:00Z