Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism.
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Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomesActive site distortion is sufficient for proteinase inhibition by serpins: structure of the covalent complex of alpha1-proteinase inhibitor with porcine pancreatic elastaseCanonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinasesAntithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activationX-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensationSerpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functionsMolecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complexAn overview of the serpin superfamilyA nonsense polymorphism in the protein Z-dependent protease inhibitor increases the risk for venous thrombosisThrombin inhibition by the serpinsSerpin polymerization is prevented by a hydrogen bond network that is centered on his-334 and stabilized by glycerolStructure of native protein C inhibitor provides insight into its multiple functionsC1 inhibitor serpin domain structure reveals the likely mechanism of heparin potentiation and conformational diseaseCorticosteroid-binding globulin, a structural basis for steroid transport and proteinase-triggered releaseCrystallographic and Cellular Characterisation of Two Mechanisms Stabilising the Native Fold of α1-Antitrypsin: Implications for Disease and Drug DesignMolecular basis of thrombomodulin activation of slow thrombinCrystal structure of native Anopheles gambiae serpin-2, a negative regulator of melanization in mosquitoesHeparin binds lamprey angiotensinogen and promotes thrombin inhibition through a template mechanismStudies on the effect of calcium in interactions between heparin and heparin cofactor II using surface plasmon resonanceMolecular mapping of the thrombin-heparin cofactor II complexIdentification of myxomaviral serpin reactive site loop sequences that regulate innate immune responsesBiochemical characterization of Anopheles gambiae SRPN6, a malaria parasite invasion marker in mosquitoesTowards engineering hormone-binding globulins as drug delivery agentsMolecular recognition mechanisms of thrombin.Glycosaminoglycan-binding properties and kinetic characterization of human heparin cofactor II expressed in Escherichia coliUnderstanding Dermatan Sulfate-Heparin Cofactor II Interaction through Virtual Library ScreeningSucrose octasulfate selectively accelerates thrombin inactivation by heparin cofactor IISulodexide ameliorates early but not late kidney disease in models of radiation nephropathy and diabetic nephropathy.Inhibition of thrombin formation by active site mutated (S360A) activated protein C.Retention of thrombin inhibitory activity by recombinant serpins expressed as integral membrane proteins tethered to the surface of mammalian cells.Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin.Allosteric activation of antithrombin critically depends upon hinge region extension.On the specificity of heparin/heparan sulfate binding to proteins. Anion-binding sites on antithrombin and thrombin are fundamentally different.Sulodexide: a renewed interest in this glycosaminoglycan.The complete N-terminal extension of heparin cofactor II is required for maximal effectiveness as a thrombin exosite 1 ligand.Fusion of the C-terminal triskaidecapeptide of hirudin variant 3 to alpha1-proteinase inhibitor M358R increases the serpin-mediated rate of thrombin inhibition.Structural and inhibitory effects of hinge loop mutagenesis in serpin-2 from the malaria vector Anopheles gambiae.Mechanisms of glycosaminoglycan activation of the serpins in hemostasis.ANISERP: a new serpin from the parasite Anisakis simplex.Heparin-binding domains in vascular biology.
P2860
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P2860
Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism.
description
2002 nî lūn-bûn
@nan
2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Crystal structures of native a ...... multistep allosteric mechanism
@nl
Crystal structures of native a ...... ultistep allosteric mechanism.
@ast
Crystal structures of native a ...... ultistep allosteric mechanism.
@en
Crystal structures of native a ...... ultistep allosteric mechanism.
@en-gb
type
label
Crystal structures of native a ...... multistep allosteric mechanism
@nl
Crystal structures of native a ...... ultistep allosteric mechanism.
@ast
Crystal structures of native a ...... ultistep allosteric mechanism.
@en
Crystal structures of native a ...... ultistep allosteric mechanism.
@en-gb
prefLabel
Crystal structures of native a ...... multistep allosteric mechanism
@nl
Crystal structures of native a ...... ultistep allosteric mechanism.
@ast
Crystal structures of native a ...... ultistep allosteric mechanism.
@en
Crystal structures of native a ...... ultistep allosteric mechanism.
@en-gb
P2093
P2860
P356
P1476
Crystal structures of native a ...... ultistep allosteric mechanism.
@en
P2093
Charles T Esmon
Frank C Church
James A Huntington
Robin W Carrell
Trevor P Baglin
P2860
P304
11079-11084
P356
10.1073/PNAS.162232399
P407
P577
2002-08-08T00:00:00Z