Structural evidence for a pH-sensitive dilysine trigger in the hen ovotransferrin N-lobe: implications for transferrin iron release
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Transferrin-mediated cellular iron deliveryAlternative structural state of transferrin. The crystallographic analysis of iron-loaded but domain-opened ovotransferrin N-lobeCrystal structure of hen apo-ovotransferrin. Both lobes adopt an open conformation upon loss of ironCrystal structures of two mutants (K206Q, H207E) of the N-lobe of human transferrin with increased affinity for ironAnion-mediated Fe3+ release mechanism in ovotransferrin C-lobe: a structurally identified SO4(2-) binding site and its implications for the kinetic pathwayThe structure and evolution of the murine inhibitor of carbonic anhydrase: A member of the transferrin superfamilyMode of binding of anti-P-glycoprotein antibody MRK-16 to its antigen. A crystallographic and molecular modeling studyA novel murine protein with no effect on iron homoeostasis is homologous with transferrin and is the putative inhibitor of carbonic anhydraseEvolution reversed: the ability to bind iron restored to the N-lobe of the murine inhibitor of carbonic anhydrase by strategic mutagenesisEmpirical relationships between protein structure and carboxyl pKa values in proteins.Dealing with iron: common structural principles in proteins that transport iron and heme.Regulation of a mammalian Shaker-related potassium channel, hKv1.5, by extracellular potassium and pH.The unique kinetics of iron release from transferrin: the role of receptor, lobe-lobe interactions, and salt at endosomal pHGating of inward-rectifier K+ channels by intracellular pH.A computational study of the open and closed forms of the N-lobe human serum transferrin apoprotein.Lactoferrin and transferrin: functional variations on a common structural framework.Intracellular trafficking considerations in the development of natural ligand-drug molecular conjugates for cancer.On the evolutionary significance and metal-binding characteristics of a monolobal transferrin from Ciona intestinalis.The long history of iron in the Universe and in health and disease.The crystal structure of iron-free human serum transferrin provides insight into inter-lobe communication and receptor binding.Identification of a titratable lysine residue that determines sensitivity of kidney potassium channels (ROMK) to intracellular pH.Intracellular pH sensors: design principles and functional significance.pH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndromeHuman serum transferrin: a tale of two lobes. Urea gel and steady state fluorescence analysis of recombinant transferrins as a function of pH, time, and the soluble portion of the transferrin receptor.Kinetics of iron release from transferrin bound to the transferrin receptor at endosomal pH.A structural perspective on lactoferrin function.Aluminium in biological environments: a computational approach.Mutations at nonliganding residues Tyr-85 and Glu-83 in the N-lobe of human serum transferrin. Functional second shell effects.The pH-induced release of iron from transferrin investigated with a continuum electrostatic model.Regulation of mammalian iron metabolism: current state and need for further knowledge.The effect of salt and site-directed mutations on the iron(III)-binding site of human serum transferrin as probed by EPR spectroscopyHuman serum transferrin: is there a link among autism, high oxalate levels, and iron deficiency anemia?Isolated rat hepatocytes differentially bind and internalize bovine lactoferrin N- and C-lobes.A conserved glutamic acid bridge in serine carboxypeptidases, belonging to the alpha/beta hydrolase fold, acts as a pH-dependent protein-stabilizing element.Structural and functional consequences of removal of the interdomain disulfide bridge from the isolated C-lobe of ovotransferrinThe chloride effect is related to anion binding in determining the rate of iron release from the human transferrin N-lobe.The low pKa value of iron-binding ligand Tyr188 and its implication in iron release and anion binding of human transferrin.Iron release from recombinant N-lobe and single point Asp63 mutants of human transferrin by EDTA.Rapid fractionation of bovine transferrin using immobilized gangliosides.UV Raman evidence of a tyrosine in apo-human serum transferrin with a low pK(a) that is elevated upon binding of sulphate.
P2860
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P2860
Structural evidence for a pH-sensitive dilysine trigger in the hen ovotransferrin N-lobe: implications for transferrin iron release
description
1993 nî lūn-bûn
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1993 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Structural evidence for a pH-s ...... s for transferrin iron release
@ast
Structural evidence for a pH-s ...... s for transferrin iron release
@en
Structural evidence for a pH-s ...... s for transferrin iron release
@nl
type
label
Structural evidence for a pH-s ...... s for transferrin iron release
@ast
Structural evidence for a pH-s ...... s for transferrin iron release
@en
Structural evidence for a pH-s ...... s for transferrin iron release
@nl
prefLabel
Structural evidence for a pH-s ...... s for transferrin iron release
@ast
Structural evidence for a pH-s ...... s for transferrin iron release
@en
Structural evidence for a pH-s ...... s for transferrin iron release
@nl
P2093
P356
P1433
P1476
Structural evidence for a pH-s ...... s for transferrin iron release
@en
P2093
J C Sacchettini
P304
P356
10.1021/BI00096A004
P407
P577
1993-11-16T00:00:00Z