Regulation of a mammalian Shaker-related potassium channel, hKv1.5, by extracellular potassium and pH.
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Rapid induction of P/C-type inactivation is the mechanism for acid-induced K+ current inhibitionEffect of external pH on activation of the Kv1.5 potassium channelSpreading acidification and depression in the cerebellar cortex.Inhibition of K(Ca)2.2 and K(Ca)2.3 channel currents by protonation of outer pore histidine residues.Molecular determinants of the inhibition of human Kv1.5 potassium currents by external protons and Zn(2+).Kinetic analysis of the effects of H+ or Ni2+ on Kv1.5 current shows that both ions enhance slow inactivation and induce resting inactivation.External Ba2+ block of human Kv1.5 at neutral and acidic pH: evidence for Ho+-induced constriction of the outer pore mouth at rest.SCAM analysis reveals a discrete region of the pore turret that modulates slow inactivation in Kv1.5.The external K+ concentration and mutations in the outer pore mouth affect the inhibition of kv1.5 current by Ni2+.Voltage clamp fluorimetry reveals a novel outer pore instability in a mammalian voltage-gated potassium channel.A direct demonstration of closed-state inactivation of K+ channels at low pH.Outer pore residues control the H(+) and K(+) sensitivity of the Arabidopsis potassium channel AKT3.ShakerIR and Kv1.5 mutant channels with enhanced slow inactivation also exhibit K⁺ o-dependent resting inactivation.Proton block of the pore underlies the inhibition of hERG cardiac K+ channels during acidosis.Regulation by external K+ in a maize inward shaker channel targets transport activity in the high concentration range.Regulation of human cardiac Kv1.5 channels by extracellular acidification.
P2860
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P2860
Regulation of a mammalian Shaker-related potassium channel, hKv1.5, by extracellular potassium and pH.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Regulation of a mammalian Shak ...... xtracellular potassium and pH.
@ast
Regulation of a mammalian Shak ...... xtracellular potassium and pH.
@en
type
label
Regulation of a mammalian Shak ...... xtracellular potassium and pH.
@ast
Regulation of a mammalian Shak ...... xtracellular potassium and pH.
@en
prefLabel
Regulation of a mammalian Shak ...... xtracellular potassium and pH.
@ast
Regulation of a mammalian Shak ...... xtracellular potassium and pH.
@en
P2860
P1433
P1476
Regulation of a mammalian Shak ...... xtracellular potassium and pH.
@en
P2093
P2860
P356
10.1016/S0014-5793(00)02396-6
P407
P577
2001-01-01T00:00:00Z