Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
about
In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysisARSACS, a spastic ataxia common in northeastern Québec, is caused by mutations in a new gene encoding an 11.5-kb ORFHeat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetasesBinding of aryl hydrocarbon receptor (AhR) to AhR-interacting protein - The role of hsp90Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinaseHsp90: a specialized but essential protein-folding toolAha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperoneInteraction of Hsp90 with ribosomal proteins protects from ubiquitination and proteasome-dependent degradationCrystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complexAkt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 functionCharacterization of the interactions between mammalian PAZ PIWI domain proteins and DicerGlial cell line-derived neurotrophic factor reverses ethanol-mediated increases in tyrosine hydroxylase immunoreactivity via altering the activity of heat shock protein 90Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexesHsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cellsGenetic and biochemical analysis of p23 and ansamycin antibiotics in the function of Hsp90-dependent signaling proteinsPerturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasomeGenetic analysis of viable Hsp90 alleles reveals a critical role in Drosophila spermatogenesisp50(cdc37) acting in concert with Hsp90 is required for Raf-1 functionThe N-terminal adenosine triphosphate binding domain of Hsp90 is necessary and sufficient for interaction with estrogen receptorCrystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyraseThe ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domainsModulation of Akt kinase activity by binding to Hsp90Structure of pyruvate dehydrogenase kinase. Novel folding pattern for a serine protein kinaseStructures of GRP94-nucleotide complexes reveal mechanistic differences between the hsp90 chaperonesThe heat shock protein 90 of Plasmodium falciparum and antimalarial activity of its inhibitor, geldanamycinInhibition of archaeal growth and DNA topoisomerase VI activities by the Hsp90 inhibitor radicicolMechanisms of Hsp90 regulationParalog Specific Hsp90 Inhibitors - A Brief History and a Bright FutureReview: The HSP90 molecular chaperone-an enigmatic ATPaseMaximizing the Therapeutic Potential of HSP90 InhibitorsSubstrate recognition and function of the R2TP complex in response to cellular stressThe 'active life' of Hsp90 complexesQuality control and fate determination of Hsp90 client proteinsPositive or negative involvement of heat shock proteins in multiple sclerosis pathogenesis: an overviewLysosomal storage diseases and the heat shock response: convergences and therapeutic opportunitiesAdvances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancersFunctions of the Hsp90 chaperone system: lifting client proteins to new heightsHsp90 selectively modulates phenotype in vertebrate developmentStructural and mutational analysis of the PhoQ histidine kinase catalytic domain. Insight into the reaction mechanism
P2860
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P2860
Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
description
1997 nî lūn-bûn
@nan
1997 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Identification and structural ...... the Hsp90 molecular chaperone
@ast
Identification and structural ...... the Hsp90 molecular chaperone
@en
Identification and structural ...... the Hsp90 molecular chaperone
@nl
type
label
Identification and structural ...... the Hsp90 molecular chaperone
@ast
Identification and structural ...... the Hsp90 molecular chaperone
@en
Identification and structural ...... the Hsp90 molecular chaperone
@nl
prefLabel
Identification and structural ...... the Hsp90 molecular chaperone
@ast
Identification and structural ...... the Hsp90 molecular chaperone
@en
Identification and structural ...... the Hsp90 molecular chaperone
@nl
P2093
P3181
P1433
P1476
Identification and structural ...... the Hsp90 molecular chaperone
@en
P2093
P3181
P356
10.1016/S0092-8674(00)80314-1
P407
P577
1997-07-01T00:00:00Z