The three-dimensional high resolution structure of human interferon alpha-2a determined by heteronuclear NMR spectroscopy in solution
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Intermolecular Interactions in a 44 kDa Interferon−Receptor Complex Detected by Asymmetric Reverse-Protonation and Two-Dimensional NOESYObservation of Intermolecular Interactions in Large Protein Complexes by 2D-Double Difference Nuclear Overhauser Enhancement Spectroscopy: Application to the 44 kDa Interferon–Receptor ComplexA Single N-Acetylgalactosamine Residue at Threonine 106 Modifies the Dynamics and Structure of Interferon 2a around the Glycosylation SiteStructural and dynamic determinants of type I interferon receptor assembly and their functional interpretation.Interferons, interferon-like cytokines, and their receptorsTherapeutic alpha-interferons protein: structure, production, and biosimilar.Effects of localized interactions and surface properties on stability of protein-based therapeutics.Use of nitrocellulose films for affinity-directed mass spectrometry for the analysis of antibody/antigen interactions.An interferon alpha2 mutant optimized by phage display for IFNAR1 binding confers specifically enhanced antitumor activities.High yield soluble bacterial expression and streamlined purification of recombinant human interferon α-2a.Structure of the interferon-receptor complex determined by distance constraints from double-mutant cycles and flexible docking.Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions.In silico identification of an interferon inhibitor.The differential antiviral activities of chicken interferon α (ChIFN-α) and ChIFN-β are related to distinct interferon-stimulated gene expression.Role of benzyl alcohol in the unfolding and aggregation of interferon α-2a.Total chemical synthesis of human interferon alpha-2b via native chemical ligationEnhancing Pharmacokinetics, Tumor Accumulation, and Antitumor Efficacy by Elastin-Like Polypeptide Fusion of Interferon Alpha.Conformational analysis of therapeutic proteins by hydroxyl radical protein footprintingCX, DPX, and PCW: Web Servers for the Visualization of Interior and Protruding Regions of Protein Structures in 3D and 1D.Expression profiles of human interferon-alpha and interferon-lambda subtypes are ligand- and cell-dependent.Determination of the human type I interferon receptor binding site on human interferon-alpha2 by cross saturation and an NMR-based model of the complex.The role of interferons in early pregnancy.Improved biological and transcriptional activity of monopegylated interferon-alpha-2a isomers.IFNA2: The prototypic human alpha interferon.NMR mapping of the IFNAR1-EC binding site on IFNalpha2 reveals allosteric changes in the IFNAR2-EC binding site.Type I interferons in the treatment of pancreatic cancer: mechanisms of action and role of related receptors.Site of pegylation and polyethylene glycol molecule size attenuate interferon-alpha antiviral and antiproliferative activities through the JAK/STAT signaling pathway.Optimizing the binding affinity of a carrier protein: a case study on the interaction between soluble ifnar2 and interferon beta.New structural and functional aspects of the type I interferon-receptor interaction revealed by comprehensive mutational analysis of the binding interface.Suitable experimental conditions are required to characterize interferon-alpha2b synthetic peptides.Evolution of a cytokine using DNA family shuffling.Real-time observation of protein aggregates in pharmaceutical formulations using liquid cell electron microscopy.Structural Insights into the Neutralization Properties of the Fully Human, Anti-interferon Monoclonal Antibody Sifalimumab.The EM structure of a type I interferon-receptor complex reveals a novel mechanism for cytokine signaling.Polyethylene glycol-induced precipitation of interferon alpha-2a followed by vacuum drying: development of a novel process for obtaining a dry, stable powderCrystallization and preliminary X-ray diffraction analysis of the complex between a human anti-interferon antibody fragment and human interferon alpha-2A.Characterization of a soluble ternary complex formed between human interferon-beta-1a and its receptor chains.Interferon dimers: IFN-PEG-IFN.Differential expression and activity of the porcine type I interferon family.Photodegradation mechanism and reaction kinetics of recombinant human interferon-alpha2a.
P2860
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P2860
The three-dimensional high resolution structure of human interferon alpha-2a determined by heteronuclear NMR spectroscopy in solution
description
1997 nî lūn-bûn
@nan
1997 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
name
The three-dimensional high res ...... r NMR spectroscopy in solution
@ast
The three-dimensional high res ...... r NMR spectroscopy in solution
@en
The three-dimensional high res ...... r NMR spectroscopy in solution
@nl
type
label
The three-dimensional high res ...... r NMR spectroscopy in solution
@ast
The three-dimensional high res ...... r NMR spectroscopy in solution
@en
The three-dimensional high res ...... r NMR spectroscopy in solution
@nl
prefLabel
The three-dimensional high res ...... r NMR spectroscopy in solution
@ast
The three-dimensional high res ...... r NMR spectroscopy in solution
@en
The three-dimensional high res ...... r NMR spectroscopy in solution
@nl
P2093
P356
P1476
The three-dimensional high res ...... r NMR spectroscopy in solution
@en
P2093
P304
P356
10.1006/JMBI.1997.1396
P407
P577
1997-12-12T00:00:00Z