Atomic structure of progesterone complexed with its receptor
about
A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivoRepressors of androgen and progesterone receptor actionStructure and function of steroid receptor AF1 transactivation domains: induction of active conformationsElectrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifsGlucocorticoid receptor homodimers and glucocorticoid-mineralocorticoid receptor heterodimers form in the cytoplasm through alternative dimerization interfacesMembrane-bound progesterone receptors contain a cytochrome b5-like ligand-binding domainThe xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CARComparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinityCrystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acidEstrogen receptor transcription and transactivation: Structure-function relationship in DNA- and ligand-binding domains of estrogen receptorsImplications of the small number of distinct ligand binding pockets in proteins for drug discovery, evolution and biochemical functionStructural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutationsStructural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helixCrystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosteroneThe three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonismThe three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligandsCrystal structure of the heterodimeric complex of LXR and RXR ligand-binding domains in a fully agonistic conformationStructural plasticity in the oestrogen receptor ligand-binding domainDoubling the Size of the Glucocorticoid Receptor Ligand Binding Pocket by DeacylcortivazolThe X-ray Structure of RU486 Bound to the Progesterone Receptor in a Destabilized Agonistic ConformationStructural Basis for Agonism and Antagonism for a Set of Chemically Related Progesterone Receptor ModulatorsX-ray Structures of Progesterone Receptor Ligand Binding Domain in Its Agonist State Reveal Differing Mechanisms for Mixed Profiles of 11 -Substituted SteroidsX-Ray Crystal Structure of the Ancestral 3-Ketosteroid Receptor–Progesterone–Mifepristone Complex Shows Mifepristone Bound at the Coactivator Binding InterfaceStructures and mechanism for the design of highly potent glucocorticoidsStructure and specificity of nuclear receptor-coactivator interactionsCrystal structure of the ligand binding domain of the human nuclear receptor PPARgammaUnconventional endocannabinoid signaling governs sperm activation via the sex hormone progesteroneJAB1 interacts with both the progesterone receptor and SRC-1From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivatorAndrogen receptor interacts with the positive elongation factor P-TEFb and enhances the efficiency of transcriptional elongationA point mutation of the AF2 transactivation domain of the glucocorticoid receptor disrupts its interaction with steroid receptor coactivator 1Kaempferol Exhibits Progestogenic Effects in Ovariectomized RatsConversion of mammalian 3alpha-hydroxysteroid dehydrogenase to 20alpha-hydroxysteroid dehydrogenase using loop chimeras: changing specificity from androgens to progestinsFunctional probing of the human glucocorticoid receptor steroid-interacting surface by site-directed mutagenesis. Gln-642 plays an important role in steroid recognition and binding3D model of lamprey estrogen receptor with estradiol and 15alpha-hydroxy-estradiolMutations at positions 547-553 of rat glucocorticoid receptors reveal that hsp90 binding requires the presence, but not defined composition, of a seven-amino acid sequence at the amino terminus of the ligand binding domainSteroid receptor coactivator-1 from brain physically interacts differentially with steroid receptor subtypesA single glycine-alanine exchange directs ligand specificity of the elephant progestin receptorSequence annotation of nuclear receptor ligand-binding domains by automated homology modeling.Overview of protein structural and functional folds.
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P2860
Atomic structure of progesterone complexed with its receptor
description
1998 nî lūn-bûn
@nan
1998 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Atomic structure of progesterone complexed with its receptor
@ast
Atomic structure of progesterone complexed with its receptor
@en
Atomic structure of progesterone complexed with its receptor
@nl
type
label
Atomic structure of progesterone complexed with its receptor
@ast
Atomic structure of progesterone complexed with its receptor
@en
Atomic structure of progesterone complexed with its receptor
@nl
prefLabel
Atomic structure of progesterone complexed with its receptor
@ast
Atomic structure of progesterone complexed with its receptor
@en
Atomic structure of progesterone complexed with its receptor
@nl
P2860
P3181
P356
P1433
P1476
Atomic structure of progesterone complexed with its receptor
@en
P2093
P B Sigler
S P Williams
P2860
P2888
P3181
P356
10.1038/30775
P407
P577
1998-05-28T00:00:00Z
P6179
1044852483