Understanding the role of the essential Asp251 in cytochrome p450cam using site-directed mutagenesis, crystallography, and kinetic solvent isotope effect
about
Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymesProton delivery in NO reduction by fungal nitric-oxide reductase. Cryogenic crystallography, spectroscopy, and kinetics of ferric-NO complexes of wild-type and mutant enzymesCrystal structure of OxyB, a cytochrome P450 implicated in an oxidative phenol coupling reaction during vancomycin biosynthesisThe 1.92-A structure of Streptomyces coelicolor A3(2) CYP154C1. A new monooxygenase that functionalizes macrolide ring systemsThe 1.5-Å Structure of XplA-heme, an Unusual Cytochrome P450 Heme Domain That Catalyzes Reductive Biotransformation of Royal Demolition ExplosiveActive Site Threonine Facilitates Proton Transfer during Dioxygen Activation at the Diiron Center of Toluene/ o -Xylene Monooxygenase HydroxylaseThe structure of CYP101D2 unveils a potential path for substrate entry into the active siteStructural Analysis of CYP101C1 from Novosphingobium aromaticivorans DSM12444Structure and function of CYP108D1 from Novosphingobium aromaticivorans DSM12444: an aromatic hydrocarbon-binding P450 enzymeP450cin Active Site Water: Implications for Substrate Binding and Solvent AccessibilitySynergistic Effects of Mutations in Cytochrome P450cam Designed To Mimic CYP101D1Crystal Structures and Functional Characterization of Wild-Type CYP101D1 and Its Active Site MutantsIdentifying proteins that can form tyrosine-cysteine crosslinks.Three clusters of conformational states in p450cam reveal a multistep pathway for closing of the substrate access channel.Coupling and uncoupling mechanisms in the methoxythreonine mutant of cytochrome P450cam: a quantum mechanical/molecular mechanical study.How does the reductase help to regulate the catalytic cycle of cytochrome P450 3A4 using the conserved water channel?Spin equilibrium and O₂-binding kinetics of Mycobacterium tuberculosis CYP51 with mutations in the histidine-threonine dyadKinetic solvent isotope effect in steady-state turnover by CYP19A1 suggests involvement of Compound 1 for both hydroxylation and aromatization steps.Solvent isotope effects on alkane formation by cyanobacterial aldehyde deformylating oxygenase and their mechanistic implicationsFormation of transient oxygen complexes of cytochrome p450 BM3 and nitric oxide synthase under high pressure.Structural differences between soluble and membrane bound cytochrome P450sHeme enzyme structure and function.Role of active site water molecules and substrate hydroxyl groups in oxygen activation by cytochrome P450 158A2: a new mechanism of proton transfer.Targeting of the highly conserved threonine 302 residue of cytochromes P450 2B family during mechanism-based inactivation by aryl acetylenesProton-coupled electron transfer: the mechanistic underpinning for radical transport and catalysis in biology.Spring-loading the active site of cytochrome P450cam.The role of copper and protons in heme-copper oxidases: kinetic study of an engineered heme-copper center in myoglobin.Mechanistic enzymology of oxygen activation by the cytochromes P450.Mechanistic studies of reactions of peroxodiiron(III) intermediates in T201 variants of toluene/o-xylene monooxygenase hydroxylaseResonance Raman characterization of the peroxo and hydroperoxo intermediates in cytochrome P450.Active-site hydration and water diffusion in cytochrome P450cam: a highly dynamic process.Deuterium isotope effect on the intramolecular electron transfer in Pseudomonas aeruginosa azurin.Analysis of cytochrome P450 CYP119 ligand-dependent conformational dynamics by two-dimensional NMR and X-ray crystallography.Models and mechanisms of O-O bond activation by cytochrome P450. A critical assessment of the potential role of multiple active intermediates in oxidative catalysis.Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdomsIdentification of a cyclosporine-specific P450 hydroxylase gene through targeted cytochrome P450 complement (CYPome) disruption in Sebekia benihana.Conformational selectivity in cytochrome P450 redox partner interactionsOxygen activation by cytochrome P450 monooxygenaseRole of the highly conserved threonine in cytochrome P450 2E1: prevention of H2O2-induced inactivation during electron transferKinetic solvent isotope effect in human P450 CYP17A1-mediated androgen formation: evidence for a reactive peroxoanion intermediate.
P2860
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P2860
Understanding the role of the essential Asp251 in cytochrome p450cam using site-directed mutagenesis, crystallography, and kinetic solvent isotope effect
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Understanding the role of the ...... kinetic solvent isotope effect
@ast
Understanding the role of the ...... kinetic solvent isotope effect
@en
Understanding the role of the ...... kinetic solvent isotope effect
@nl
type
label
Understanding the role of the ...... kinetic solvent isotope effect
@ast
Understanding the role of the ...... kinetic solvent isotope effect
@en
Understanding the role of the ...... kinetic solvent isotope effect
@nl
prefLabel
Understanding the role of the ...... kinetic solvent isotope effect
@ast
Understanding the role of the ...... kinetic solvent isotope effect
@en
Understanding the role of the ...... kinetic solvent isotope effect
@nl
P2093
P356
P1433
P1476
Understanding the role of the ...... kinetic solvent isotope effect
@en
P2093
P304
P356
10.1021/BI980189F
P407
P577
1998-06-30T00:00:00Z