Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids.
about
Dynamic Ca2+-dependent stimulation of vesicle fusion by membrane-anchored synaptotagmin 1Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helixComplexins: small but capableSynaptic vesicle recycling: steps and principlesMolecular machines governing exocytosis of synaptic vesiclesA Chemical Controller of SNARE-Driven Membrane Fusion That Primes Vesicles for Ca(2+)-Triggered Millisecond ExocytosisHelical extension of the neuronal SNARE complex into the membraneMolecular mechanism of the synaptotagmin–SNARE interaction in Ca2+-triggered vesicle fusionThe importance of an asymmetric distribution of acidic lipids for synaptotagmin 1 function as a Ca2+ sensorCis- and trans-membrane interactions of synaptotagmin-1Analysis of the synaptotagmin family during reconstituted membrane fusion. Uncovering a class of inhibitory isoformsSynaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusionSNARE-fusion mediated insertion of membrane proteins into native and artificial membranes.PtdInsP2 and PtdSer cooperate to trap synaptotagmin-1 to the plasma membrane in the presence of calcium.Munc18-1 and the Syntaxin-1 N Terminus Regulate Open-Closed States in a t-SNARE Complex.Synaptotagmin-1 binds to PIP(2)-containing membrane but not to SNAREs at physiological ionic strengthHigh cholesterol obviates a prolonged hemifusion intermediate in fast SNARE-mediated membrane fusionReconstituting SNARE-mediated membrane fusion at the single liposome level.The juxtamembrane linker of full-length synaptotagmin 1 controls oligomerization and calcium-dependent membrane binding.Rapid fusion of synaptic vesicles with reconstituted target SNARE membranesPartitioning of synaptotagmin I C2 domains between liquid-ordered and liquid-disordered inner leaflet lipid phasesPhosphatidylinositol 4,5-bisphosphate alters synaptotagmin 1 membrane docking and drives opposing bilayers closer together.Single SNARE-mediated vesicle fusion observed in vitro by polarized TIRFMDocking and fast fusion of synaptobrevin vesicles depends on the lipid compositions of the vesicle and the acceptor SNARE complex-containing target membrane.Single vesicle millisecond fusion kinetics reveals number of SNARE complexes optimal for fast SNARE-mediated membrane fusion.Solution and membrane-bound conformations of the tandem C2A and C2B domains of synaptotagmin 1: Evidence for bilayer bridgingClustering of syntaxin-1A in model membranes is modulated by phosphatidylinositol 4,5-bisphosphate and cholesterol.The calcium-dependent and calcium-independent membrane binding of synaptotagmin 1: two modes of C2B binding.Conformation and membrane position of the region linking the two C2 domains in synaptotagmin 1 by site-directed spin labeling.Tomosyn inhibits synaptotagmin-1-mediated step of Ca2+-dependent neurotransmitter release through its N-terminal WD40 repeats.In vitro system capable of differentiating fast Ca2+-triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter releaseCalcium regulates molecular interactions of otoferlin with soluble NSF attachment protein receptor (SNARE) proteins required for hair cell exocytosis.C2-domain mediated nano-cluster formation increases calcium signaling efficiency.Cross-linking of phospholipid membranes is a conserved property of calcium-sensitive synaptotagminsInteraction of synaptotagmin with lipid bilayers, analyzed by single-molecule force spectroscopy.Single-molecule studies of the neuronal SNARE fusion machinery.Accessory proteins stabilize the acceptor complex for synaptobrevin, the 1:1 syntaxin/SNAP-25 complexDocking, not fusion, as the rate-limiting step in a SNARE-driven vesicle fusion assayRegulation of Weibel-Palade body exocytosis by alpha-synuclein in endothelial cells.Protein determinants of SNARE-mediated lipid mixing.
P2860
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P2860
Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids.
description
2007 nî lūn-bûn
@nan
2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Synaptotagmin activates membra ...... nteraction with phospholipids.
@ast
Synaptotagmin activates membra ...... nteraction with phospholipids.
@en
Synaptotagmin activates membra ...... nteraction with phospholipids.
@nl
type
label
Synaptotagmin activates membra ...... nteraction with phospholipids.
@ast
Synaptotagmin activates membra ...... nteraction with phospholipids.
@en
Synaptotagmin activates membra ...... nteraction with phospholipids.
@nl
altLabel
Synaptotagmin activates membra ...... interaction with phospholipids
@en
prefLabel
Synaptotagmin activates membra ...... nteraction with phospholipids.
@ast
Synaptotagmin activates membra ...... nteraction with phospholipids.
@en
Synaptotagmin activates membra ...... nteraction with phospholipids.
@nl
P50
P3181
P356
P1476
Synaptotagmin activates membra ...... nteraction with phospholipids.
@en
P2093
Anand Radhakrishnan
Dietmar Riedel
P2860
P2888
P304
P3181
P356
10.1038/NSMB1305
P407
P577
2007-10-01T00:00:00Z
P6179
1052514256