A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: implications for filovirus budding
about
Discovery of an ebolavirus-like filovirus in europeDivergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteinsISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activityOverexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain functionLate assembly domain function can exhibit context dependence and involves ubiquitin residues implicated in endocytosis.Overlapping motifs (PTAP and PPEY) within the Ebola virus VP40 protein function independently as late budding domains: involvement of host proteins TSG101 and VPS-4.Retroviruses have differing requirements for proteasome function in the budding processRole of ESCRT-I in retroviral buddingThe ESCRT complexesThe ESCRT-associated protein Alix recruits the ubiquitin ligase Nedd4-1 to facilitate HIV-1 release through the LYPXnL L domain motifNedd4 controls animal growth by regulating IGF-1 signalingTsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55(Gag)Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functionsVacuolar protein sorting pathway contributes to the release of Marburg virusNo strings attached: the ESCRT machinery in viral budding and cytokinesisEquine infectious anemia virus utilizes host vesicular protein sorting machinery during particle releasePackaging of actin into Ebola virus VLPs.Viral membrane scissionMarburg Virus Evades Interferon Responses by a Mechanism Distinct from Ebola VirusStructure and functional interactions of the Tsg101 UEV domain.Crystal structure of vesicular stomatitis virus matrix protein.Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life CycleDirect binding to Rsp5p regulates ubiquitination-independent vacuolar transport of Sna3p.Direct binding to Rsp5 mediates ubiquitin-independent sorting of Sna3 via the multivesicular body pathway.Bsd2 binds the ubiquitin ligase Rsp5 and mediates the ubiquitination of transmembrane proteins.ESCRT-independent budding of HIV-1 gag virus-like particles from Saccharomyces cerevisiae spheroplastsMultiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infectionThe ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3The multifunctional Ebola virus VP40 matrix protein is a promising therapeutic target.Rhabdoviruses and the cellular ubiquitin-proteasome system: a budding interaction.Assembly and budding of Ebolavirus.Mapping of the VP40-binding regions of the nucleoprotein of Ebola virus.A filovirus-unique region of Ebola virus nucleoprotein confers aberrant migration and mediates its incorporation into virions.The HECT domain of the ubiquitin ligase Rsp5 contributes to substrate recognitionInteraction between Ebola virus glycoprotein and host toll-like receptor 4 leads to induction of proinflammatory cytokines and SOCS1.PIV5 M protein interaction with host protein angiomotin-like 1Identification of essential filovirion-associated host factors by serial proteomic analysis and RNAi screen.VP40 octamers are essential for Ebola virus replication.Association of ebola virus matrix protein VP40 with microtubules.
P2860
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P2860
A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: implications for filovirus budding
description
2000 nî lūn-bûn
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2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
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2000年论文
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name
A PPxY motif within the VP40 p ...... ications for filovirus budding
@ast
A PPxY motif within the VP40 p ...... ications for filovirus budding
@en
A PPxY motif within the VP40 p ...... cations for filovirus budding.
@nl
type
label
A PPxY motif within the VP40 p ...... ications for filovirus budding
@ast
A PPxY motif within the VP40 p ...... ications for filovirus budding
@en
A PPxY motif within the VP40 p ...... cations for filovirus budding.
@nl
altLabel
A PPxY motif within the VP40 p ...... ications for filovirus budding
@en
prefLabel
A PPxY motif within the VP40 p ...... ications for filovirus budding
@ast
A PPxY motif within the VP40 p ...... ications for filovirus budding
@en
A PPxY motif within the VP40 p ...... cations for filovirus budding.
@nl
P2093
P2860
P3181
P356
P1476
A PPxY motif within the VP40 p ...... ications for filovirus budding
@en
P2093
P2860
P304
P3181
P356
10.1073/PNAS.250277297
P407
P577
2000-12-05T00:00:00Z