Differential structural properties of GLP-1 and exendin-4 determine their relative affinity for the GLP-1 receptor N-terminal extracellular domain.
about
Landmark studies on the glucagon subfamily of GPCRs: from small molecule modulators to a crystal structureCrystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domainCrystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 ReceptorGlucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic SuccessesStructural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R)Glucagon-like peptide-1 receptor ligand interactions: structural cross talk between ligands and the extracellular domainStructural study of an active analog of EX-4 in solution and micelle associated states.Purification of family B G protein-coupled receptors using nanodiscs: Application to human glucagon-like peptide-1 receptorDifferences in acute anorectic effects of long-acting GLP-1 receptor agonists in rats.Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secreting progenySite-specific PEGylation of exenatide analogues markedly improved their glucoregulatory activityBiophysical characterization of G-protein coupled receptor-peptide ligand binding.Glucagon-like peptide-1 (GLP-1) analogs: recent advances, new possibilities, and therapeutic implications.Differences in the central anorectic effects of glucagon-like peptide-1 and exendin-4 in rats.The structure and function of the glucagon-like peptide-1 receptor and its ligandsPhysiology and emerging biochemistry of the glucagon-like peptide-1 receptor.Isolation of Positive Modulator of Glucagon-like Peptide-1 Signaling from Trigonella foenum-graecum (Fenugreek) Seed.Charge inversion at position 68 of the glucagon and glucagon-like peptide-1 receptors supports selectivity in hormone action.The major determinant of exendin-4/glucagon-like peptide 1 differential affinity at the rat glucagon-like peptide 1 receptor N-terminal domain is a hydrogen bond from SER-32 of exendin-4.Exenatide: a new promising antidiabetic agentA hydrophobic site on the GLP-1 receptor extracellular domain orients the peptide ligand for signal transductionType II Turn of Receptor-bound Salmon Calcitonin Revealed by X-ray Crystallography.Structural insight into antibody-mediated antagonism of the Glucagon-like peptide-1 Receptor.Residues within the transmembrane domain of the glucagon-like peptide-1 receptor involved in ligand binding and receptor activation: modelling the ligand-bound receptor.Monotreme glucagon-like peptide-1 in venom and gut: one gene - two very different functions.The predicted binding site and dynamics of peptide inhibitors to the Methuselah GPCR from Drosophila melanogaster.N-Glycosylation of Asparagine 130 in the Extracellular Domain of the Human Calcitonin Receptor Significantly Increases Peptide Hormone Affinity.Exendin-4 promotes the osteogenic differentiation of osteoblasts via the Hedgehog/Gli1 signaling pathway.Glucagon-like Peptide-1 Receptor (GLP1R) binds Glucagon-like peptide-1Functional association of the N-terminal residues with the central region in glucagon-related peptides.Does glucagon-like peptide-1 (GLP-1) receptor agonist stimulation reduce alcohol intake in patients with alcohol dependence: study protocol of a randomised, double-blinded, placebo-controlled clinical trial
P2860
Q26798049-C8E42E26-6564-4195-8418-343650B662EDQ27649890-6D66554C-C962-458E-8BAE-1D9C431444EBQ27657999-2C5FB838-D600-4DE5-A3CB-DD4358BEFE6CQ28067465-95806478-26D5-4345-94C8-1BA2EBF9FC4CQ28274664-1296D89A-66FB-44B3-ABB3-517BFAB4E290Q28542687-1EABE3B4-3A2A-4CA7-8831-4CFD7B98176FQ33745444-D5C53FAB-4D86-4C70-AC41-32B90E5773EEQ33793135-B95D2954-CC18-4A64-9140-1AFE76104B24Q33959406-76EE9167-2953-4B2A-BC01-D1A8ABCDE7A1Q34692148-42C7B70D-A897-44D9-9B1F-78230B95BFDDQ34919698-48FB8715-B675-4B4B-88DF-46E85DBC45C0Q34987728-5E706C0D-90BA-487D-AED7-0EE77AA83722Q35087846-E824ADEF-73ED-4466-B0B7-688324E0F816Q37429168-C3925B8A-8C58-47D3-A94C-AC0F5C29CBD3Q37939244-2A350831-5F71-414B-A5B4-CA013EA16FB8Q38016154-6510B2CD-EB23-4B96-8547-841280922FC9Q38838276-773118E4-BCAD-4AED-8A22-4881BCA2E448Q39594833-55222481-7387-4368-943A-9F110CF7D4DAQ39677369-9A779422-CE5C-45CA-AF05-4743447174ACQ40964981-CBA95B61-D0E9-4DDC-9BB7-895A2C91EDA5Q42002273-93111C41-6AF5-47F1-8F8D-F7F41A96EE25Q42103047-2CEBE5F3-7376-4E2D-AC4E-A2CAA18DE91FQ42266832-F1B94F88-78F2-47FA-B3DA-3A3283BDF960Q42289659-CC0CCDB0-EEE8-4B5E-88B2-385FE86B0CD9Q42362229-111A4C1B-146F-480E-BF67-4E83A735D307Q42736248-E09ED181-9C2C-4A3D-9734-3B2C603BD807Q46350132-F52DFA6E-4751-4656-8E09-BE1D60002031Q49371368-8C2670B1-CCA1-457B-A1F3-EE08D9FD4EC3Q50294368-F7784D99-9DC4-45DE-A194-40940CDAB3B1Q53241623-094A4CB9-EF47-4F7A-9F1F-35CF01640743Q56517489-2F9F11C0-708E-4098-A704-7F7E80F9A595
P2860
Differential structural properties of GLP-1 and exendin-4 determine their relative affinity for the GLP-1 receptor N-terminal extracellular domain.
description
2007 nî lūn-bûn
@nan
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Differential structural proper ...... terminal extracellular domain.
@ast
Differential structural proper ...... terminal extracellular domain.
@en
Differential structural proper ...... terminal extracellular domain.
@nl
type
label
Differential structural proper ...... terminal extracellular domain.
@ast
Differential structural proper ...... terminal extracellular domain.
@en
Differential structural proper ...... terminal extracellular domain.
@nl
altLabel
Differential structural proper ...... -terminal extracellular domain
@en
prefLabel
Differential structural proper ...... terminal extracellular domain.
@ast
Differential structural proper ...... terminal extracellular domain.
@en
Differential structural proper ...... terminal extracellular domain.
@nl
P2093
P3181
P356
P1433
P1476
Differential structural proper ...... terminal extracellular domain.
@en
P2093
Christine Bruun Schiødt
Claus Bekker Jeppesen
Henning Thøgersen
Jan Oschmann
Jesper Lau
Kjeld Madsen
Rainer Rudolph
Sanne Möller Knudsen
Steffen Runge
Susann Schimmer
P304
P3181
P356
10.1021/BI062309M
P407
P577
2007-05-15T00:00:00Z