Pif1 family helicases suppress genome instability at G-quadruplex motifs.
about
G-quadruplexes and helicasesLinking replication stress with heterochromatin formationG-quadruplexes and their regulatory roles in biologyRoles of DNA helicases in the maintenance of genome integrityReplication protein A prevents promiscuous annealing between short sequence homologies: Implications for genome integrityG-quadruplex formation in double strand DNA probed by NMM and CV fluorescence.Rad53-Mediated Regulation of Rrm3 and Pif1 DNA Helicases Contributes to Prevention of Aberrant Fork Transitions under Replication Stress.Yeast Pif1 accelerates annealing of complementary DNA strands.G-quadruplexes in pathogens: a common route to virulence control?G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptomeA remarkable career in science-Joseph G. GallIdentification of genomic features in environmentally induced epigenetic transgenerational inherited sperm epimutationsPfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome IntegrityThe DNA structure and sequence preferences of WRN underlie its function in telomeric recombination eventsSingle-molecule imaging reveals a common mechanism shared by G-quadruplex-resolving helicasesRPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome endsCrystal structures of the BsPif1 helicase reveal that a major movement of the 2B SH3 domain is required for DNA unwindingThe Human CCHC-type Zinc Finger Nucleic Acid-Binding Protein Binds G-Rich Elements in Target mRNA Coding Sequences and Promotes Translation.PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes.Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNAInactivation of Pif1 helicase causes a mitochondrial myopathy in miceAtaxin-2: From RNA Control to Human Health and DiseasePathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiaePif1 regulates telomere length by preferentially removing telomerase from long telomere endsAssociation of G-quadruplex forming sequences with human mtDNA deletion breakpoints.RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATPCauses and consequences of replication stress.DNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative Twinkle helicase.Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structuresImpact of G-quadruplex structures and intronic polymorphisms rs17878362 and rs1642785 on basal and ionizing radiation-induced expression of alternative p53 transcriptsThe Pif1 family helicase Pfh1 facilitates telomere replication and has an RPA-dependent role during telomere lengthening.The RNA helicase RHAU (DHX36) suppresses expression of the transcription factor PITX1.Insights into the mechanism of a G-quadruplex-unwinding DEAH-box helicase.Telomeric overhang length determines structural dynamics and accessibility to telomerase and ALT-associated proteinsA parallel quadruplex DNA is bound tightly but unfolded slowly by pif1 helicase.G-quadruplexes significantly stimulate Pif1 helicase-catalyzed duplex DNA unwinding.Elevated levels of G-quadruplex formation in human stomach and liver cancer tissues.The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damageTopoisomerase I plays a critical role in suppressing genome instability at a highly transcribed G-quadruplex-forming sequence.A fluorescence-based helicase assay: application to the screening of G-quadruplex ligands.
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P2860
Pif1 family helicases suppress genome instability at G-quadruplex motifs.
description
2013 nî lūn-bûn
@nan
2013 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Pif1 family helicases suppress genome instability at G-quadruplex motifs.
@ast
Pif1 family helicases suppress genome instability at G-quadruplex motifs.
@en
Pif1 family helicases suppress genome instability at G-quadruplex motifs.
@nl
type
label
Pif1 family helicases suppress genome instability at G-quadruplex motifs.
@ast
Pif1 family helicases suppress genome instability at G-quadruplex motifs.
@en
Pif1 family helicases suppress genome instability at G-quadruplex motifs.
@nl
prefLabel
Pif1 family helicases suppress genome instability at G-quadruplex motifs.
@ast
Pif1 family helicases suppress genome instability at G-quadruplex motifs.
@en
Pif1 family helicases suppress genome instability at G-quadruplex motifs.
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
Pif1 family helicases suppress genome instability at G-quadruplex motifs.
@en
P2093
Katherine L Friedman
Katrin Paeschke
Matthew L Bochman
P Daniela Garcia
Petr Cejka
Stephen C Kowalczykowski
Virginia A Zakian
P2860
P2888
P304
P3181
P356
10.1038/NATURE12149
P407
P577
2013-05-23T00:00:00Z
P5875
P6179
1008760038