Topoisomerase I plays a critical role in suppressing genome instability at a highly transcribed G-quadruplex-forming sequence.

Topoisomerase I plays a critical role in suppressing genome instability at a highly transcribed G-quadruplex-forming sequence.

Item
http://www.wikidata.org/entity/Q35488141
Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNAG Quadruplex in Plants: A Ubiquitous Regulatory Element and Its Biological Relevance.Sites of instability in the human TCF3 (E2A) gene adopt G-quadruplex DNA structures in vitroTopoisomerase 1-dependent deletions initiated by incision at ribonucleotides are biased to the non-transcribed strand of a highly activated reporter.The role of topoisomerase I in suppressing genome instability associated with a highly transcribed guanine-rich sequence is not restricted to preventing RNA:DNA hybrid accumulation.Translocation and deletion breakpoints in cancer genomes are associated with potential non-B DNA-forming sequencesRNA Polymerase Collision versus DNA Structural Distortion: Twists and Turns Can Cause Break FailureThe Top1 paradox: Friend and foe of the eukaryotic genome.Polymorphisms, Chromosomal Rearrangements, and Mutator Phenotype Development during Experimental Evolution of Lactobacillus rhamnosus GG.Dissecting the Roles of Divergent and Convergent Transcription in Chromosome Instability.AID and Reactive Oxygen Species Can Induce DNA Breaks within Human Chromosomal Translocation Fragile Zones.Topoisomerase IB of Deinococcus radiodurans resolves guanine quadruplex DNA structures in vitro.Topoisomerase I and Genome Stability: The Good and the Bad.Def1 and Dst1 play distinct roles in repair of AP lesions in highly transcribed genomic regions.The interplay between G-quadruplex and Transcription.
P2860

Topoisomerase I plays a critical role in suppressing genome instability at a highly transcribed G-quadruplex-forming sequence.

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http://www.wikidata.org/entity/Q35488141
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2014 nî lūn-bûn
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2014 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
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2014 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年學術文章
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Topoisomerase I plays a critic ...... G-quadruplex-forming sequence.
@ast
Topoisomerase I plays a critic ...... G-quadruplex-forming sequence.
@en
type
label
Topoisomerase I plays a critic ...... G-quadruplex-forming sequence.
@ast
Topoisomerase I plays a critic ...... G-quadruplex-forming sequence.
@en
prefLabel
Topoisomerase I plays a critic ...... G-quadruplex-forming sequence.
@ast
Topoisomerase I plays a critic ...... G-quadruplex-forming sequence.
@en
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Topoisomerase I plays a critic ...... G-quadruplex-forming sequence.
@en
P2093
P2860
P304
P31
P356
10.1371/JOURNAL.PGEN.1004839
P433
P478
P50
P577
P5875
P698
P932