Genetic analysis reveals a role for the C terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activation
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The network of protein-protein interactions within the human U4/U6.U5 tri-snRNPHaploinsufficiency of a spliceosomal GTPase encoded by EFTUD2 causes mandibulofacial dysostosis with microcephalyRNA helicases in splicingStructural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2The Prp19 WD40 Domain Contains a Conserved Protein Interaction Region Essential for Its FunctionStructural basis for dual roles of Aar2p in U5 snRNP assemblyAssembly of Snu114 into U5 snRNP requires Prp8 and a functional GTPase domain.The Isy1p component of the NineTeen complex interacts with the ATPase Prp16p to regulate the fidelity of pre-mRNA splicing.Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing.Spliceosome Structure and FunctionInteraction between RNA helicase ROOT INITIATION DEFECTIVE 1 and GAMETOPHYTIC FACTOR 1 is involved in female gametophyte development in Arabidopsis.Spliceosomal protein eftud2 mutation leads to p53-dependent apoptosis in zebrafish neural progenitors.From the ribosome to the spliceosome and back again.A bird's-eye view of post-translational modifications in the spliceosome and their roles in spliceosome dynamicsA mutation in a splicing factor that causes retinitis pigmentosa has a transcriptome-wide effect on mRNA splicing.Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis.Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p.Brr2 plays a role in spliceosomal activation in addition to U4/U6 unwinding.BRR2a Affects Flowering Time via FLC SplicingFunctional roles of protein splicing factors.A dynamic bulge in the U6 RNA internal stem-loop functions in spliceosome assembly and activation.Spliceosome activation: U4 is the path, stem I is the goal, and Prp8 is the keeper. Let's cheer for the ATPase Brr2!The EF-G-like GTPase Snu114p regulates spliceosome dynamics mediated by Brr2p, a DExD/H box ATPaseAssembly of ribosomes and spliceosomes: complex ribonucleoprotein machinesATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8.A role for ubiquitin in the spliceosome assembly pathway.Mutations in the Saccharomyces cerevisiae kinase Cbk1p lead to a fertility defect that can be suppressed by the absence of Brr1p or Mpt5p (Puf5p), proteins involved in RNA metabolism.Physical and genetic interactions of yeast Cwc21p, an ortholog of human SRm300/SRRM2, suggest a role at the catalytic center of the spliceosome.Sad1 counteracts Brr2-mediated dissociation of U4/U6.U5 in tri-snRNP homeostasis.A review of craniofacial disorders caused by spliceosomal defects.Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution.Functions and regulation of the Brr2 RNA helicase during splicing.The U5 snRNA internal loop 1 is a platform for Brr2, Snu114 and Prp8 protein binding during U5 snRNP assembly.Cwc21p promotes the second step conformation of the spliceosome and modulates 3' splice site selection.Structural and functional characterization of the N terminus of Schizosaccharomyces pombe Cwf10.Analysis of synthetic lethality reveals genetic interactions between the GTPase Snu114p and snRNAs in the catalytic core of the Saccharomyces cerevisiae spliceosome.Prp8 positioning of U5 snRNA is linked to 5' splice site recognition.
P2860
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P2860
Genetic analysis reveals a role for the C terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activation
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2005 nî lūn-bûn
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2005 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հուլիսին հրատարակված գիտական հոդված
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2005年の論文
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2005年論文
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2005年論文
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2005年論文
@zh-hk
2005年論文
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2005年論文
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2005年论文
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Genetic analysis reveals a rol ...... during spliceosome activation
@ast
Genetic analysis reveals a rol ...... during spliceosome activation
@en
Genetic analysis reveals a rol ...... during spliceosome activation.
@nl
type
label
Genetic analysis reveals a rol ...... during spliceosome activation
@ast
Genetic analysis reveals a rol ...... during spliceosome activation
@en
Genetic analysis reveals a rol ...... during spliceosome activation.
@nl
prefLabel
Genetic analysis reveals a rol ...... during spliceosome activation
@ast
Genetic analysis reveals a rol ...... during spliceosome activation
@en
Genetic analysis reveals a rol ...... during spliceosome activation.
@nl
P2860
P3181
P1433
P1476
Genetic analysis reveals a rol ...... during spliceosome activation
@en
P2093
Christine Guthrie
Tamara J Brenner
P2860
P304
P3181
P356
10.1534/GENETICS.105.042044
P407
P577
2005-07-01T00:00:00Z