The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP
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Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosomeA dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assemblyThe architecture of the spliceosomal U4/U6.U5 tri-snRNP.Crystal structure of the C-terminal domain of splicing factor Prp8 carrying retinitis pigmentosa mutantsStructural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2Mechanism for Aar2p function as a U5 snRNP assembly factorStructural Basis of Brr2-Prp8 Interactions and Implications for U5 snRNP Biogenesis and the Spliceosome Active SiteThe conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cellsA noncanonical PWI domain in the N-terminal helicase-associated region of the spliceosomal Brr2 proteinStructure of a yeast spliceosome at 3.6-angstrom resolutionPrp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing.A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing.Splicing factor SPF30 bridges an interaction between the prespliceosome protein U2AF35 and tri-small nuclear ribonucleoprotein protein hPrp3Genome-wide DNA methylation analysis of patients with imprinting disorders identifies differentially methylated regions associated with novel candidate imprinted genesIn vivo kinetics of U4/U6·U5 tri-snRNP formation in Cajal bodies.A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing.Knockdown of ubiquitin-specific peptidase 39 inhibited the growth of osteosarcoma cells and induced apoptosis in vitro.Mutations in spliceosomal proteins and retina degenerationMutational screening of splicing factor genes in cases with autosomal dominant retinitis pigmentosaZebrafish usp39 mutation leads to rb1 mRNA splicing defect and pituitary lineage expansionTemporal and tissue specific regulation of RP-associated splicing factor genes PRPF3, PRPF31 and PRPC8--implications in the pathogenesis of RP.Cytoplasmic viral RNA-dependent RNA polymerase disrupts the intracellular splicing machinery by entering the nucleus and interfering with Prp8Mutations in ASCC3L1 on 2q11.2 are associated with autosomal dominant retinitis pigmentosa in a Chinese family.A functional genomic screen reveals novel host genes that mediate interferon-alpha's effects against hepatitis C virus.Ribonucleoprotein multimers and their functions.Dominant PRPF31 mutations are hypostatic to a recessive CNOT3 polymorphism in retinitis pigmentosa: a novel phenomenon of "linked trans-acting epistasis".Compound heterozygosity of low-frequency promoter deletions and rare loss-of-function mutations in TXNL4A causes Burn-McKeown syndrome.PRPF mutations are associated with generalized defects in spliceosome formation and pre-mRNA splicing in patients with retinitis pigmentosa.A missense mutation in PRPF6 causes impairment of pre-mRNA splicing and autosomal-dominant retinitis pigmentosaMutant Prpf31 causes pre-mRNA splicing defects and rod photoreceptor cell degeneration in a zebrafish model for Retinitis pigmentosa.Transcriptome analysis of the white body of the squid Euprymna tasmanica with emphasis on immune and hematopoietic gene discovery.Knocking Down Snrnp200 Initiates Demorphogenesis of Rod Photoreceptors in Zebrafish.RNA binding and RNA remodeling activities of the half-a-tetratricopeptide (HAT) protein HCF107 underlie its effects on gene expression.FgPrp4 Kinase Is Important for Spliceosome B-Complex Activation and Splicing Efficiency in Fusarium graminearum.Mutations in Splicing Factor Genes Are a Major Cause of Autosomal Dominant Retinitis Pigmentosa in Belgian FamiliesModeling of autosomal-dominant retinitis pigmentosa in Caenorhabditis elegans uncovers a nexus between global impaired functioning of certain splicing factors and cell type-specific apoptosis.Dynamic interactions of Ntr1-Ntr2 with Prp43 and with U5 govern the recruitment of Prp43 to mediate spliceosome disassemblyBrr2p-mediated conformational rearrangements in the spliceosome during activation and substrate repositioningTranscriptional regulation of PRPF31 gene expression by MSR1 repeat elements causes incomplete penetrance in retinitis pigmentosa.Structural requirements for protein-catalyzed annealing of U4 and U6 RNAs during di-snRNP assembly.
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The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP
description
2006 nî lūn-bûn
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2006 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2006年の論文
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2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
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name
The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP
@ast
The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP
@en
The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP
@nl
type
label
The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP
@ast
The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP
@en
The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP
@nl
prefLabel
The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP
@ast
The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP
@en
The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP
@nl
P2860
P3181
P356
P1433
P1476
The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP
@en
P2093
Reinhard Rauhut
Sunbin Liu
P2860
P304
P3181
P356
10.1261/RNA.55406
P407
P577
2006-07-01T00:00:00Z