Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1.
about
Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substratesThe N-end rule pathwayHECT and RING finger families of E3 ubiquitin ligases at a glanceSelective destruction of abnormal proteins by ubiquitin-mediated protein quality control degradationMolecular chaperones in targeting misfolded proteins for ubiquitin-dependent degradationQuality control and fate determination of Hsp90 client proteinsProtein quality control in the nucleusPreviously unknown role for the ubiquitin ligase Ubr1 in endoplasmic reticulum-associated protein degradation.Ubr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins.Prefoldin Promotes Proteasomal Degradation of Cytosolic Proteins with Missense Mutations by Maintaining Substrate Solubility.Life-span extension by a metacaspase in the yeast Saccharomyces cerevisiae.Hsp70 nucleotide exchange factor Fes1 is essential for ubiquitin-dependent degradation of misfolded cytosolic proteins.The yeast ubr1 ubiquitin ligase participates in a prominent pathway that targets cytosolic thermosensitive mutants for degradationGlutamine-specific N-terminal amidase, a component of the N-end rule pathwayRibosomal proteins produced in excess are degraded by the ubiquitin-proteasome systemThe UBR-box and its relationship to binuclear RING-like treble clef zinc fingersAblation of arginylation in the mouse N-end rule pathway: loss of fat, higher metabolic rate, damaged spermatogenesis, and neurological perturbations.A nucleus-based quality control mechanism for cytosolic proteinsUbiquitin ligases of the N-end rule pathway: assessment of mutations in UBR1 that cause the Johanson-Blizzard syndromeThe N-end rule pathway and regulation by proteolysisCrystal structure of human protein N-terminal glutamine amidohydrolase, an initial component of the N-end rule pathway.Ser(120) of Ubc2/Rad6 regulates ubiquitin-dependent N-end rule targeting by E3{alpha}/Ubr1The Type II Hsp40 Sis1 cooperates with Hsp70 and the E3 ligase Ubr1 to promote degradation of terminally misfolded cytosolic protein.Expression and biochemical characterization of the human enzyme N-terminal asparagine amidohydrolase.Cytosolic aggregates perturb the degradation of nontranslocated secretory and membrane proteinsProtein targeting and degradation are coupled for elimination of mislocalized proteins.Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.Compartment-specific aggregases direct distinct nuclear and cytoplasmic aggregate deposition.UBR1 promotes protein kinase quality control and sensitizes cells to Hsp90 inhibition.Hsp70 clears misfolded kinases that partitioned into distinct quality-control compartments.Absence of the Yeast Hsp31 Chaperones of the DJ-1 Superfamily Perturbs Cytoplasmic Protein Quality Control in Late Growth Phase.Degradation Signals for Ubiquitin-Proteasome Dependent Cytosolic Protein Quality Control (CytoQC) in YeastA network of ubiquitin ligases is important for the dynamics of misfolded protein aggregates in yeast.The ubiquitin-proteasome system of Saccharomyces cerevisiae.Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: a hypothesis.Ubiquitin receptors and protein quality controlPositional proteomics reveals differences in N-terminal proteoform stability.Cytosolic splice isoform of Hsp70 nucleotide exchange factor Fes1 is required for the degradation of misfolded proteins in yeastSpecificity in the actions of the UBR1 ubiquitin ligase in the degradation of nuclear receptors.
P2860
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P2860
Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1.
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Degradation of misfolded prote ...... by the ubiquitin ligase Ubr1.
@ast
Degradation of misfolded prote ...... by the ubiquitin ligase Ubr1.
@en
Degradation of misfolded prote ...... by the ubiquitin ligase Ubr1.
@nl
type
label
Degradation of misfolded prote ...... by the ubiquitin ligase Ubr1.
@ast
Degradation of misfolded prote ...... by the ubiquitin ligase Ubr1.
@en
Degradation of misfolded prote ...... by the ubiquitin ligase Ubr1.
@nl
prefLabel
Degradation of misfolded prote ...... by the ubiquitin ligase Ubr1.
@ast
Degradation of misfolded prote ...... by the ubiquitin ligase Ubr1.
@en
Degradation of misfolded prote ...... by the ubiquitin ligase Ubr1.
@nl
P2860
P3181
P1433
P1476
Degradation of misfolded prote ...... by the ubiquitin ligase Ubr1.
@en
P2093
Dieter H Wolf
Frederik Eisele
P2860
P304
P3181
P356
10.1016/J.FEBSLET.2008.11.015
P407
P577
2008-12-24T00:00:00Z