MUS81 encodes a novel helix-hairpin-helix protein involved in the response to UV- and methylation-induced DNA damage in Saccharomyces cerevisiae.
about
Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substratesIdentification and characterization of human MUS81-MMS4 structure-specific endonucleaseMethyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks.Holliday junction resolution in human cells: two junction endonucleases with distinct substrate specificitiesHaploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cellsDamage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1Homologous recombination in DNA repair and DNA damage toleranceMus81 endonuclease localizes to nucleoli and to regions of DNA damage in human S-phase cellsRNA interference inhibition of Mus81 reduces mitotic recombination in human cellsEme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cellsMus81 functions in the quality control of replication forks at the rDNA and is involved in the maintenance of rDNA repeat number in Saccharomyces cerevisiaeHold your horSSEs: controlling structure-selective endonucleases MUS81 and Yen1/GEN1A role for MMS4 in the processing of recombination intermediates during meiosis in Saccharomyces cerevisiaeFunctional overlap between Sgs1-Top3 and the Mms4-Mus81 endonucleaseMus81 cleavage of Holliday junctions: a failsafe for processing meiotic recombination intermediates?RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination.Cooperativity of Mus81.Mms4 with Rad54 in the resolution of recombination and replication intermediates.Srs2 promotes Mus81-Mms4-mediated resolution of recombination intermediates.Activity of individual ERCC1 and XPF subunits in DNA nucleotide excision repairChecking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressorThe active site of the DNA repair endonuclease XPF-ERCC1 forms a highly conserved nuclease motif.Interplay between structure-specific endonucleases for crossover control during Caenorhabditis elegans meiosisRole of RAD52 epistasis group genes in homologous recombination and double-strand break repairMarrow stem cells shift gene expression and engraftment phenotype with cell cycle transitThe role of AtMUS81 in interference-insensitive crossovers in A. thalianaEffects of mutations in SGS1 and in genes functionally related to SGS1 on inverted repeat-stimulated spontaneous unequal sister-chromatid exchange in yeastSingle Holliday junctions are intermediates of meiotic recombination.Biochemistry of Meiotic Recombination: Formation, Processing, and Resolution of Recombination Intermediates.Human MUS81-EME2 can cleave a variety of DNA structures including intact Holliday junction and nicked duplex.The Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage.Substrate preference of Gen endonucleases highlights the importance of branched structures as DNA damage repair intermediates.Meiotic recombination intermediates are resolved with minimal crossover formation during return-to-growth, an analogue of the mitotic cell cycleDisruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis.The Smc5-Smc6 complex is required to remove chromosome junctions in meiosis.Mechanism of Holliday junction resolution by the human GEN1 proteinProcessing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes.Three structure-selective endonucleases are essential in the absence of BLM helicase in Drosophila.Identification and characterization of the human mus81-eme1 endonuclease.SLX-1 is required for maintaining genomic integrity and promoting meiotic noncrossovers in the Caenorhabditis elegans germline.Inhibition of Mus81 by siRNA enhances sensitivity to 5-FU in breast carcinoma cell lines.
P2860
Q24294687-BB76746E-9AAE-4648-B2E1-14F94CFF7C2DQ24299599-02931180-1CC9-4256-950E-17D7A3C0A9D5Q24531151-46DA4CCB-F927-4477-8855-280136CB1C33Q24534960-D71BB754-0AFA-49C3-A7E9-B48877026CFBQ24537482-77BCF4A7-939C-47E4-9377-80A13A3B7143Q24551095-65F94961-C6C8-4D70-8C90-83DF1E6FBEEFQ24601150-2EACBBF6-334E-4030-853A-8DC5008ABE87Q24607828-46B289F0-2169-4FBB-A66B-CA0651941974Q24627013-560DF8AC-9158-43E6-8AE8-AF41D771E89DQ24644518-54163A24-3D1C-4C97-A9F3-CE6C97BF472FQ24684096-F7DD857C-8BB6-45FB-936A-D2CA0AA1E0A3Q26797303-B8763F5C-CC73-453E-A62E-13A33D2D16C4Q27935770-F5547408-E89B-49D1-A1B1-A2EE122F29EEQ27935913-91FAB0F3-3A38-4665-959D-4B005DA7A977Q27936167-D6D610BF-9169-4AE1-A29D-7822E6C53D38Q27939265-F9A25B6A-CE88-43A9-9682-E48E2AB1B7F4Q27939352-40B6BC62-E7C2-4150-B3A9-E6D0C79CA0D2Q27940191-C3847E63-9A38-44CD-9B2D-6541835E8433Q28143061-C86FF1B7-46B1-4429-9B48-05F646BA0106Q28214285-23F643DB-17EF-480D-A244-0CB5B79E674AQ28214697-F62CB6C4-01C3-4CDE-B9C2-435A6B686E24Q28513559-5E9B2676-A6A5-4D72-B470-5D1F3768D59FQ29618204-DAA37011-469F-4AB0-9D8A-BF7066581537Q33187250-BDC68F9C-6805-4CC5-AD94-ADBEF3BD30F5Q33294063-6CAF52A8-E985-4C6A-9409-0D441F1E8F40Q33312867-E2BE9862-53BC-421A-BC59-DDF22F4527BEQ33576921-1509DB19-13A6-46FF-8C60-14C16763423DQ33604620-AFC6E7C8-98A9-4F48-9E6B-AA8570BA0DCEQ33635502-8A52AB71-A92B-4352-A14D-3BD9D154107AQ33698561-512280BC-4421-46E7-A65D-4CD6B1DCE2E9Q33701418-2102D264-6715-4B55-8342-ADBDA15FD74DQ33921194-40F7D9B7-EAD4-4A05-8FB7-EC7F78BE1554Q33925085-90306D1F-B5EF-4ECF-81D1-950B8F26AEE9Q33952127-9F307711-E033-4E78-B2AB-2131F6286A77Q33998890-0312A403-7C35-42C0-B505-3ED846E9F467Q34025948-177F7DF3-EB83-4DB7-B90B-C161C5A48272Q34055346-A97F56CD-97E1-4E9C-84D6-5DAED90876B3Q34193657-4A1F6F7F-3DBA-4EBC-8956-D0219E7418AFQ34395310-6F4D3629-DD66-452C-A6DD-2761003E8521Q34415337-2D90FA9F-5132-4AC3-B152-7A2B82C5C4F7
P2860
MUS81 encodes a novel helix-hairpin-helix protein involved in the response to UV- and methylation-induced DNA damage in Saccharomyces cerevisiae.
description
2000 nî lūn-bûn
@nan
2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
MUS81 encodes a novel helix-ha ...... e in Saccharomyces cerevisiae.
@ast
MUS81 encodes a novel helix-ha ...... e in Saccharomyces cerevisiae.
@en
MUS81 encodes a novel helix-ha ...... e in Saccharomyces cerevisiae.
@nl
type
label
MUS81 encodes a novel helix-ha ...... e in Saccharomyces cerevisiae.
@ast
MUS81 encodes a novel helix-ha ...... e in Saccharomyces cerevisiae.
@en
MUS81 encodes a novel helix-ha ...... e in Saccharomyces cerevisiae.
@nl
prefLabel
MUS81 encodes a novel helix-ha ...... e in Saccharomyces cerevisiae.
@ast
MUS81 encodes a novel helix-ha ...... e in Saccharomyces cerevisiae.
@en
MUS81 encodes a novel helix-ha ...... e in Saccharomyces cerevisiae.
@nl
P921
P356
P1476
MUS81 encodes a novel helix-ha ...... e in Saccharomyces cerevisiae.
@en
P2093
H Interthal
P2888
P304
P356
10.1007/S004380000241
P407
P577
2000-06-01T00:00:00Z
P5875
P6179
1052238278