Mus81 cleavage of Holliday junctions: a failsafe for processing meiotic recombination intermediates?
about
Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substratesHuman SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleasesMus81 functions in the quality control of replication forks at the rDNA and is involved in the maintenance of rDNA repeat number in Saccharomyces cerevisiaeHold your horSSEs: controlling structure-selective endonucleases MUS81 and Yen1/GEN1Nucleases in homologous recombination as targets for cancer therapySmc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisionsCrystal structure of the Mus81-Eme1 complexGenetic analysis of mlh3 mutations reveals interactions between crossover promoting factors during meiosis in baker's yeast.RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination.Cooperativity of Mus81.Mms4 with Rad54 in the resolution of recombination and replication intermediates.Mus81/Mms4 endonuclease and Sgs1 helicase collaborate to ensure proper recombination intermediate metabolism during meiosis.The fission yeast FANCM ortholog directs non-crossover recombination during meiosisEfficient second strand cleavage during Holliday junction resolution by RuvC requires both increased junction flexibility and an exposed 5' phosphate.MUS81 generates a subset of MLH1-MLH3-independent crossovers in mammalian meiosis.Biochemistry of Meiotic Recombination: Formation, Processing, and Resolution of Recombination Intermediates.Human MUS81-EME2 can cleave a variety of DNA structures including intact Holliday junction and nicked duplex.The Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage.Meiotic recombination intermediates are resolved with minimal crossover formation during return-to-growth, an analogue of the mitotic cell cycleThe search for a human Holliday junction resolvase.Mechanism of Holliday junction resolution by the human GEN1 proteinProcessing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes.Fission yeast RecQ helicase Rqh1 is required for the maintenance of circular chromosomes.Increased meiotic crossovers and reduced genome stability in absence of Schizosaccharomyces pombe Rad16 (XPF).Human Mus81 and FANCB independently contribute to repair of DNA damage during replication.Rad51/Dmc1 paralogs and mediators oppose DNA helicases to limit hybrid DNA formation and promote crossovers during meiotic recombinationDamage-dependent regulation of MUS81-EME1 by Fanconi anemia complementation group A protein.Epistasis analysis between homologous recombination genes in Saccharomyces cerevisiae identifies multiple repair pathways for Sgs1, Mus81-Mms4 and RNase H2Distinct roles of Mus81, Yen1, Slx1-Slx4, and Rad1 nucleases in the repair of replication-born double-strand breaks by sister chromatid exchangeMms22 preserves genomic integrity during DNA replication in Schizosaccharomyces pombe.Mus81-Mms4 functions as a single heterodimer to cleave nicked intermediates in recombinational DNA repair.Meiotic DNA joint molecule resolution depends on Nse5-Nse6 of the Smc5-Smc6 holocomplexFaithful after break-up: suppression of chromosomal translocations.Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structuresMus81 is essential for sister chromatid recombination at broken replication forksRegression supports two mechanisms of fork processing in phage T4.A mutation in the putative MLH3 endonuclease domain confers a defect in both mismatch repair and meiosis in Saccharomyces cerevisiae.A junction branch point adjacent to a DNA backbone nick directs substrate cleavage by Saccharomyces cerevisiae Mus81-Mms4.Genome stability roles of SUMO-targeted ubiquitin ligases.Saccharomyces cerevisiae Mus81-Mms4 is a catalytic, DNA structure-selective endonuclease.Meiotic Recombination: The Essence of Heredity.
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P2860
Mus81 cleavage of Holliday junctions: a failsafe for processing meiotic recombination intermediates?
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2007 nî lūn-bûn
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2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2007 թվականի ապրիլին հրատարակված գիտական հոդված
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2007年の論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年论文
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name
Mus81 cleavage of Holliday jun ...... c recombination intermediates?
@ast
Mus81 cleavage of Holliday jun ...... c recombination intermediates?
@en
Mus81 cleavage of Holliday jun ...... c recombination intermediates?
@nl
type
label
Mus81 cleavage of Holliday jun ...... c recombination intermediates?
@ast
Mus81 cleavage of Holliday jun ...... c recombination intermediates?
@en
Mus81 cleavage of Holliday jun ...... c recombination intermediates?
@nl
prefLabel
Mus81 cleavage of Holliday jun ...... c recombination intermediates?
@ast
Mus81 cleavage of Holliday jun ...... c recombination intermediates?
@en
Mus81 cleavage of Holliday jun ...... c recombination intermediates?
@nl
P2093
P2860
P356
P1433
P1476
Mus81 cleavage of Holliday jun ...... c recombination intermediates?
@en
P2093
Fekret Osman
Louise J Gaskell
Robert J C Gilbert
P2860
P304
P356
10.1038/SJ.EMBOJ.7601645
P407
P577
2007-04-04T00:00:00Z