Structure and functionality in flavivirus NS-proteins: perspectives for drug designStructure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancerWaaA of the hyperthermophilic bacterium Aquifex aeolicus is a monofunctional 3-deoxy-D-manno-oct-2-ulosonic acid transferase involved in lipopolysaccharide biosynthesisMolecular mechanisms of severe acute respiratory syndrome (SARS)Correction: Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main ProteasesDesign of wide-spectrum inhibitors targeting coronavirus main proteasesCrystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitorFrom SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug designThe evolution of insulin glargine and its continuing contribution to diabetes careFunctional Characterization of the Cleavage Specificity of the Sapovirus Chymotrypsin-Like ProteaseStructure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain.The active principle of garlic at atomic resolutionUnusual binding mode of an HIV-1 protease inhibitor explains its potency against multi-drug-resistant virus strainsCoronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugsThe crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitorHuman glutamate carboxypeptidase II inhibition: structures of GCPII in complex with two potent inhibitors, quisqualate and 2-PMPAA structural view of the inactivation of the SARS coronavirus main proteinase by benzotriazole estersVariable oligomerization modes in coronavirus non-structural protein 9Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved propertyThe SARS-Unique Domain (SUD) of SARS Coronavirus Contains Two Macrodomains That Bind G-QuadruplexesStructure and cleavage specificity of the chymotrypsin-like serine protease (3CLSP/nsp4) of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)Structure of the X (ADRP) domain of nsp3 from feline coronavirusStructure of the GTPase and GDI domains of FeoB, the ferrous iron transporter of Legionella pneumophilaCrystal structure of the middle domain of human poly(A)-binding protein-interacting protein 1The Legionella HtrA homologue DegQ is a self-compartmentizing protease that forms large 12-meric assembliesStructural basis for the regulation of cysteine-protease activity by a new class of protease inhibitors in PlasmodiumEvidence for a Two-Metal-Ion Mechanism in the Cytidyltransferase KdsB, an Enzyme Involved in Lipopolysaccharide BiosynthesisPeptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main proteaseX-ray structure of the SH3 domain of the phosphoinositide 3-kinase p85β subunit3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against PicornavirusesNonstructural Proteins 7 and 8 of Feline Coronavirus Form a 2:1 Heterotrimer That Exhibits Primer-Independent RNA Polymerase ActivityHelix Unfolding/Refolding Characterizes the Functional Dynamics of Staphylococcus aureus Clp ProteaseStructural and mechanistic analysis of the membrane-embedded glycosyltransferase WaaA required for lipopolysaccharide synthesisDevelopment and characterization of new peptidomimetic inhibitors of the West Nile virus NS2B-NS3 proteaseCrystal Structure of the Peroxo-diiron(III) Intermediate of Deoxyhypusine Hydroxylase, an Oxygenase Involved in HypusinationStructures of DegQ from Legionella pneumophila Define Distinct ON and OFF StatesStructural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitinExtended substrate specificity and first potent irreversible inhibitor/activity-based probe design for Zika virus NS2B-NS3 proteaseExoerythrocytic Plasmodium parasites secrete a cysteine protease inhibitor involved in sporozoite invasion and capable of blocking cell death of host hepatocytesRecent advances in targeting viral proteases for the discovery of novel antivirals.
P50
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P50
description
Duits biochemicus
@nl
deutscher Biochemiker
@de
hulumtues
@sq
researcher
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ricercatore
@it
հետազոտող
@hy
name
Rolf Hilgenfeld
@ast
Rolf Hilgenfeld
@de
Rolf Hilgenfeld
@en
Rolf Hilgenfeld
@es
Rolf Hilgenfeld
@nl
Rolf Hilgenfeld
@pl
Rolf Hilgenfeld
@sl
罗尔夫·希根菲尔德
@zh
type
label
Rolf Hilgenfeld
@ast
Rolf Hilgenfeld
@de
Rolf Hilgenfeld
@en
Rolf Hilgenfeld
@es
Rolf Hilgenfeld
@nl
Rolf Hilgenfeld
@pl
Rolf Hilgenfeld
@sl
罗尔夫·希根菲尔德
@zh
prefLabel
Rolf Hilgenfeld
@ast
Rolf Hilgenfeld
@de
Rolf Hilgenfeld
@en
Rolf Hilgenfeld
@es
Rolf Hilgenfeld
@nl
Rolf Hilgenfeld
@pl
Rolf Hilgenfeld
@sl
罗尔夫·希根菲尔德
@zh
P101
P108
P1006
P214
P227
P1006
P106
P19
P21
P214
P227
P31
P569
1954-04-03T00:00:00Z
P734
P735
P7859
lccn-n84158049