Human trk oncogenes activated by point mutation, in-frame deletion, and duplication of the tyrosine kinase domain
about
A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotypeTRKing down an old oncogene in a new era of targeted therapyIdentification of a zinc finger protein whose subcellular distribution is regulated by serum and nerve growth factorGenetic analysis of Ras signalling pathways in cell proliferation, migration and survival.Oncogenes, Protein Tyrosine Kinases, and Signal Transduction.Identification and characterization of an activating TrkA deletion mutation in acute myeloid leukemia.Response of cell cycle proteins to neurotrophic factor and chemokine stimulation in human neuroglia.Defective posttranslational processing activates the tyrosine kinase encoded by the MET proto-oncogene (hepatocyte growth factor receptor).Alternative splicing generates isoforms of the met receptor tyrosine kinase which undergo differential processingElevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancerTrkA immunoglobulin-like ligand binding domains inhibit spontaneous activation of the receptorAlternative TrkAIII splicing: a potential regulated tumor-promoting switch and therapeutic target in neuroblastoma.Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutationsThe dark side of the NGF family: neurotrophins in neoplasias.High-affinity neurotrophin receptors and ligands promote leukemogenesis.An immunoglobulin-like domain determines the specificity of neurotrophin receptors.The TPM3-NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition.Mutations in the extracellular domain cause RET loss of function by a dominant negative mechanism.Transforming properties and substrate specificities of the protein tyrosine kinase oncogenes ros and src and their recombinants.Structural and functional properties of the TRK family of neurotrophin receptors.Functional expression of TrkA receptors in hippocampal neurons.The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3.Ectopic expression of TrKA in the adult rat basal ganglia induces both nerve growth factor-dependent and -independent neuronal responses.TrkB variants with deletions in the leucine-rich motifs of the extracellular domain.A novel mutation within the extracellular domain of TrkA causes constitutive receptor activation.p75 Co-receptors regulate ligand-dependent and ligand-independent Trk receptor activation, in part by altering Trk docking subdomains.c-jun and multistage carcinogenesis: association of overexpression of introduced c-jun with progression toward a neoplastic endpoint in mouse JB6 cells sensitive to tumor promoter-induced transformation.Mutational analysis of the TrkA gene in prostate cancer.The oncogenic neurotrophin receptor tropomyosin-related kinase variant, TrkAIII.New nucleotide sequence data on the EMBL File ServerGenuine Monovalent Ligands of TrkA Nerve Growth Factor Receptors Reveal a Novel Pharmacological Mechanism of Action
P2860
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P2860
Human trk oncogenes activated by point mutation, in-frame deletion, and duplication of the tyrosine kinase domain
description
1990 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1990
@ast
im August 1990 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1990/08/01)
@sk
vědecký článek publikovaný v roce 1990
@cs
wetenschappelijk artikel (gepubliceerd op 1990/08/01)
@nl
наукова стаття, опублікована в серпні 1990
@uk
مقالة علمية (نشرت في أغسطس 1990)
@ar
name
Human trk oncogenes activated ...... of the tyrosine kinase domain
@ast
Human trk oncogenes activated ...... of the tyrosine kinase domain
@en
Human trk oncogenes activated ...... of the tyrosine kinase domain
@nl
type
label
Human trk oncogenes activated ...... of the tyrosine kinase domain
@ast
Human trk oncogenes activated ...... of the tyrosine kinase domain
@en
Human trk oncogenes activated ...... of the tyrosine kinase domain
@nl
prefLabel
Human trk oncogenes activated ...... of the tyrosine kinase domain
@ast
Human trk oncogenes activated ...... of the tyrosine kinase domain
@en
Human trk oncogenes activated ...... of the tyrosine kinase domain
@nl
P2093
P2860
P356
P1476
Human trk oncogenes activated ...... of the tyrosine kinase domain
@en
P2093
D. Martin-Zanca
F. Coulier
M. Barbacid
P2860
P304
P356
10.1128/MCB.10.8.4202
P407
P577
1990-08-01T00:00:00Z