Molecular and biochemical characterization of the human trk proto-oncogene
about
Functional analysis of H-Ryk, an atypical member of the receptor tyrosine kinase familyAn alternatively spliced fibroblast growth factor (FGF)-5 mRNA is abundant in brain and translates into a partial agonist/antagonist for FGF-5 neurotrophic activityEDF-1, a novel gene product down-regulated in human endothelial cell differentiationSortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinaseHuman platelet glycoprotein V: characterization of the polypeptide and the related Ib-V-IX receptor system of adhesive, leucine-rich glycoproteinsStructure and organization of the human TRKA gene encoding a high affinity receptor for nerve growth factorThe DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domainInteraction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptorp619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteinsIdentification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domainsAberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors.Structure-function analysis of SUV39H1 reveals a dominant role in heterochromatin organization, chromosome segregation, and mitotic progression.cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replicationOncogenic activation of the human trk proto-oncogene by recombination with the ribosomal large subunit protein L7aA receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domainReceptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiationtrkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificitiesA mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brainMechanism of activation of the human trk oncogeneBoth N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motifExpression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathwaysA splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotypeHuman trk oncogenes activated by point mutation, in-frame deletion, and duplication of the tyrosine kinase domainThe Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cellsInteractions between brain-derived neurotrophic factor and the TRKB receptor. Identification of two ligand binding domains in soluble TRKB by affinity separation and chemical cross-linkingHigh resolution mapping of the binding site of TrkA for nerve growth factor and TrkC for neurotrophin-3 on the second immunoglobulin-like domain of the Trk receptorsN-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signalingThe HIV-1 TAT protein induces the expression and extracellular appearance of acidic fibroblast growth factorThe death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kapp B signalingSpatiotemporal patterns of expression of neurotrophins and neurotrophin receptors in mice suggest functional roles in testicular and epididymal morphogenesisMolecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptorsRetrolinkin, a membrane protein, plays an important role in retrograde axonal transportTemporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiationThe role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src.Oncogenes, Protein Tyrosine Kinases, and Signal Transduction.The tyrosine kinase receptors Ron and Sea control "scattering" and morphogenesis of liver progenitor cells in vitro.Identification and characterization of an activating TrkA deletion mutation in acute myeloid leukemia.Sputa nerve growth factor forms a preferable substitute to mouse 7S-beta nerve growth factorFte-1, a v-fos transformation effector gene, encodes the mammalian homologue of a yeast gene involved in protein import into mitochondria.
P2860
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P2860
Molecular and biochemical characterization of the human trk proto-oncogene
description
1989 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1989
@ast
im Januar 1989 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
wetenschappelijk artikel (gepubliceerd op 1989/01/01)
@nl
наукова стаття, опублікована в січні 1989
@uk
مقالة علمية (نشرت عام 1989)
@ar
name
Molecular and biochemical characterization of the human trk proto-oncogene
@ast
Molecular and biochemical characterization of the human trk proto-oncogene
@en
type
label
Molecular and biochemical characterization of the human trk proto-oncogene
@ast
Molecular and biochemical characterization of the human trk proto-oncogene
@en
prefLabel
Molecular and biochemical characterization of the human trk proto-oncogene
@ast
Molecular and biochemical characterization of the human trk proto-oncogene
@en
P2093
P2860
P356
P1476
Molecular and biochemical characterization of the human trk proto-oncogene
@en
P2093
D. Martin-Zanca
M. Barbacid
T. Copeland
P2860
P356
10.1128/MCB.9.1.24
P407
P577
1989-01-01T00:00:00Z