Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin
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The 1.9 Å structure of the branched-chain amino-acid transaminase (IlvE) fromMycobacterium tuberculosisCrystal Structures of Complexes of the Branched-Chain Aminotransferase from Deinococcus radiodurans with -Ketoisocaproate and L-Glutamate Suggest the Radiation Resistance of This Enzyme for CatalysisHuman mitochondrial branched chain aminotransferase isozyme: structural role of the CXXC center in catalysisThe branched-chain aminotransferase proteins: novel redox chaperones for protein disulfide isomerase--implications in Alzheimer's diseaseDiscovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded LibraryChemical Mechanism of the Branched-Chain Aminotransferase IlvE from Mycobacterium tuberculosis.Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2-Aryl Benzimidazole BCATm InhibitorsPurification, crystallization and preliminary X-ray crystallographic analysis of branched-chain aminotransferase from Deinococcus radiodurans.BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1.Discovery and structural characterisation of new fold type IV-transaminases exemplify the diversity of this enzyme foldAssessment of bevacizumab resistance increased by expression of BCAT1 in IDH1 wild-type glioblastoma: application of DSC perfusion MR imaging.Mitochondrial toxicity of antiepileptic drugs and their tolerability in mitochondrial disorders.Hyperpolarized [1-13C] glutamate: a metabolic imaging biomarker of IDH1 mutational status in gliomaEnzymes involved in branched-chain amino acid metabolism in humans.Cannabinoid-mediated diversity of antinociceptive efficacy of parecoxib in Wistar and Sprague Dawley rats in the chronic constriction injury model of neuropathic pain.BCAA Metabolism and NH3 Homeostasis.Toxicity of Antiepileptic Drugs to Mitochondria.BCAT1 is a New MR Imaging-related Biomarker for Prognosis Prediction in IDH1-wildtype Glioblastoma Patients.Bacterial Branched-Chain Amino Acid Biosynthesis: Structures, Mechanisms, and Drugability.Valine but not leucine or isoleucine supports neurotransmitter glutamate synthesis during synaptic activity in cultured cerebellar neurons.leu; ile; or val + alpha-ketoglutarate <=> a-ketoisocaproate; a-keto-b-methylvalerate; or a-ketoisovalerate + glutamatea-ketoisocaproate; a-keto-b-methylvalerate; or a-ketoisovalerate + glutamate <=> leu; ile; or val + alpha-ketoglutarate
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P2860
Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin
description
2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2005
@ast
im November 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/11/04)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/11/04)
@nl
наукова стаття, опублікована в листопаді 2005
@uk
name
Structural determinants for br ...... anticonvulsant drug gabapentin
@ast
Structural determinants for br ...... anticonvulsant drug gabapentin
@en
Structural determinants for br ...... anticonvulsant drug gabapentin
@nl
type
label
Structural determinants for br ...... anticonvulsant drug gabapentin
@ast
Structural determinants for br ...... anticonvulsant drug gabapentin
@en
Structural determinants for br ...... anticonvulsant drug gabapentin
@nl
prefLabel
Structural determinants for br ...... anticonvulsant drug gabapentin
@ast
Structural determinants for br ...... anticonvulsant drug gabapentin
@en
Structural determinants for br ...... anticonvulsant drug gabapentin
@nl
P2093
P2860
P356
P1476
Structural determinants for br ...... anticonvulsant drug gabapentin
@en
P2093
Ikuko Miyahara
Ken Hirotsu
Masaru Goto
Mohammad M. Islam
Myra Conway
Neela Yennawar
Susan M. Hutson
P2860
P304
37246–37256
P356
10.1074/JBC.M506486200
P407
P577
2005-11-04T00:00:00Z