Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs
about
Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formationOverexpression of human alpha-galactosidase A results in its intracellular aggregation, crystallization in lysosomes, and selective secretionAn MspI polymorphism in the human acid sphingomyelinase gene (SMPD1)Niemann-Pick type B disease. Identification of a single codon deletion in the acid sphingomyelinase gene and genotype/phenotype correlations in type A and B patientsAcid sphingomyelinase possesses a domain homologous to its activator proteins: saposins B and DCharacterization of common SMPD1 mutations causing types A and B Niemann-Pick disease and generation of mutation-specific mouse modelsFunctional implications of novel human acid sphingomyelinase splice variantsExpression and regulation of enzymes in the ceramide metabolic pathway in human retinal pigment epithelial cells and their relevance to retinal degeneration.Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repair.A high-throughput sphingomyelinase assay using natural substrate.Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesisImprinting at the SMPD1 locus: implications for acid sphingomyelinase-deficient Niemann-Pick disease.A method for visualization of "omic" datasets for sphingolipid metabolism to predict potentially interesting differences.Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress.Alternative splicing of SMPD1 in human sepsis.Reproductive pathology and sperm physiology in acid sphingomyelinase-deficient miceSperm abnormalities in heterozygous acid sphingomyelinase knockout mice reveal a novel approach for the prevention of genetic diseases.Plasma Membrane Repair Is Regulated Extracellularly by Proteases Released from Lysosomes.Ceramide: a signal for apoptosis or mitogenesis?CD28 signals through acidic sphingomyelinase.Acidic sphingomyelinase (ASM) is necessary for fas-induced GD3 ganglioside accumulation and efficient apoptosis of lymphoid cellsThe Acid Sphingomyelinase Sequence Variant p.A487V Is Not Associated With Decreased Levels of Enzymatic Activity.Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.Retroviral-mediated transfer of the human acid sphingomyelinase cDNA: correction of the metabolic defect in cultured Niemann-Pick disease cellsThe demographics and distribution of type B Niemann-Pick disease: novel mutations lead to new genotype/phenotype correlations.Roles and regulation of secretory and lysosomal acid sphingomyelinase.Drug delivery by red blood cells: vascular carriers designed by mother nature.Implication of ceramide, ceramide 1-phosphate and sphingosine 1-phosphate in tumorigenesis.My journey into the world of sphingolipids and sphingolipidoses.Regulation of hematogenous tumor metastasis by acid sphingomyelinase.The sphingomyelin-ceramide pathway participates in cytokine regulation of C-reactive protein and serum amyloid A, but not alpha-fibrinogen.Occurrence of two molecular forms of human acid sphingomyelinase.Signal transduction of stress via ceramide.A model of the acid sphingomyelinase phosphoesterase domain based on its remote structural homolog purple acid phosphatase.Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells.Identification and characterization of SMPD1 mutations causing Niemann-Pick types A and B in Spanish patientsAcid sphingomyelinase activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2.Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)
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P2860
Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs
description
1991 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
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artículu científicu espublizáu en 1991
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im Mai 1991 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 1991/05/05)
@sk
vědecký článek publikovaný v roce 1991
@cs
wetenschappelijk artikel (gepubliceerd op 1991/05/05)
@nl
наукова стаття, опублікована в травні 1991
@uk
name
Human acid sphingomyelinase. I ...... nd alternatively spliced cDNAs
@ast
Human acid sphingomyelinase. I ...... nd alternatively spliced cDNAs
@en
Human acid sphingomyelinase. I ...... nd alternatively spliced cDNAs
@nl
type
label
Human acid sphingomyelinase. I ...... nd alternatively spliced cDNAs
@ast
Human acid sphingomyelinase. I ...... nd alternatively spliced cDNAs
@en
Human acid sphingomyelinase. I ...... nd alternatively spliced cDNAs
@nl
prefLabel
Human acid sphingomyelinase. I ...... nd alternatively spliced cDNAs
@ast
Human acid sphingomyelinase. I ...... nd alternatively spliced cDNAs
@en
Human acid sphingomyelinase. I ...... nd alternatively spliced cDNAs
@nl
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P3181
P1476
Human acid sphingomyelinase. I ...... nd alternatively spliced cDNAs
@en
P2093
Desnick RJ
Sandhoff K
Schuchman EH
Takahashi T
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P3181
P407
P577
1991-05-01T00:00:00Z