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Roles and regulation of secretory and lysosomal acid sphingomyelinase.

Roles and regulation of secretory and lysosomal acid sphingomyelinase.

http://www.wikidata.org/entity/Q37454661

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Identification of novel functional inhibitors of acid sphingomyelinase Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons Evolving concepts in cancer therapy through targeting sphingolipid metabolism Damage control: cellular mechanisms of plasma membrane repair Ceramides in Alzheimer's Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ Accumulation Bis(monoacylglycerol)phosphate as a non-invasive biomarker to monitor the onset and time-course of phospholipidosis with drug-induced toxicities Evaluation of the role of secretory sphingomyelinase and bioactive sphingolipids as biomarkers in hemophagocytic lymphohistiocytosis Identification and biochemical characterization of an acid sphingomyelinase-like protein from the bacterial plant pathogen Ralstonia solanacearum that hydrolyzes ATP to AMP but not sphingomyelin to ceramide Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD.Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane.Sequential action of Caenorhabditis elegans Rab GTPases regulates phagolysosome formation during apoptotic cell degradation Hyperresponsiveness of mice deficient in plasma-secreted sphingomyelinase reveals its pivotal role in early phase of host response Sphingomyelin metabolism at the plasma membrane: implications for bioactive sphingolipids.Multi-system disorders of glycosphingolipid and ganglioside metabolism Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer's disease.A high-throughput sphingomyelinase assay using natural substrate.Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation.Functional consequences of sphingomyelinase-induced changes in erythrocyte membrane structure Acid sphingomyelinase serum activity predicts mortality in intensive care unit patients after systemic inflammation: a prospective cohort study Acid sphingomyelinase deficiency attenuates bleomycin-induced lung inflammation and fibrosis in mice.Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase.S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism.Neutral sphingomyelinase-2 mediates growth arrest by retinoic acid through modulation of ribosomal S6 kinase Alternative splicing of SMPD1 in human sepsis.Sphingolipid metabolism correlates with cerebrospinal fluid Beta amyloid levels in Alzheimer's disease Cathepsin B overexpression due to acid sphingomyelinase ablation promotes liver fibrosis in Niemann-Pick disease.Computational modeling of sphingolipid metabolism.Sphingolipid and ceramide homeostasis: potential therapeutic targets.Network Analysis of a Comprehensive Knowledge Repository Reveals a Dual Role for Ceramide in Alzheimer's Disease.Plasma Membrane Repair Is Regulated Extracellularly by Proteases Released from Lysosomes.Sphingomyelin, ORAI1 channels, and cellular Ca2+ signaling.(-)-Oleocanthal rapidly and selectively induces cancer cell death via lysosomal membrane permeabilization.Safety study of adeno-associated virus serotype 2-mediated human acid sphingomyelinase expression in the nonhuman primate brain.SrfJ, a Salmonella type III secretion system effector regulated by PhoP, RcsB, and IolR.Liver acid sphingomyelinase inhibits growth of metastatic colon cancer.Genetics of Lipid-Storage Management in Caenorhabditis elegans Embryos Increased ceramide in brains with Alzheimer's and other neurodegenerative diseases ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation.

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Roles and regulation of secretory and lysosomal acid sphingomyelinase.

http://www.wikidata.org/entity/Q37454661

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article científic

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bilimsel makale

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scientific article published on June 2009

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vědecký článek

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Roles and regulation of secretory and lysosomal acid sphingomyelinase.

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Roles and regulation of secretory and lysosomal acid sphingomyelinase.

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Roles and regulation of secretory and lysosomal acid sphingomyelinase.

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Roles and regulation of secretory and lysosomal acid sphingomyelinase.

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prefLabel

Roles and regulation of secretory and lysosomal acid sphingomyelinase.

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Roles and regulation of secretory and lysosomal acid sphingomyelinase.

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J.CELLSIG.2009.01.026

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Cellular Signalling

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Roles and regulation of secretory and lysosomal acid sphingomyelinase.

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Daniel Canals

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Russell W Jenkins

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P2860

Several cooperating binding sites mediate the interaction of a lysosomal enzyme with phosphotransferase

The sphingolipid salvage pathway in ceramide metabolism and signaling

Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells

Acid sphingomyelinase possesses a domain homologous to its activator proteins: saposins B and D

Phosphoinositides in cell regulation and membrane dynamics

Structural organization and complete nucleotide sequence of the gene encoding human acid sphingomyelinase (SMPD1)

Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs

Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene

Molecular cloning of the acid sphingomyelinase of the mouse and the organization and complete nucleotide sequence of the gene

Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation

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836-846

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scholarly article

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10.1016/J.CELLSIG.2009.01.026

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6

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