ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs
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The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic miceThe neurosecretory vesicle protein phogrin functions as a phosphatidylinositol phosphatase to regulate insulin secretionHuman β-cell proliferation and intracellular signaling: part 3The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512.Specific silencing of the REST target genes in insulin-secreting cells uncovers their participation in beta cell survivalX-ray structure of the mature ectodomain of phogrinNovel interactions between NFATc1 (Nuclear Factor of Activated T cells c1) and STAT-3 (Signal Transducer and Activator of Transcription-3) mediate G protein-coupled receptor agonist, thrombin-induced biphasic expression of cyclin D1, with first phasModulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stressRegulation of insulin granule turnover in pancreatic beta-cells by cleaved ICA512.Chromosomal mapping of pancreatic islet morphological features and regulatory hormones in the spontaneously diabetic (Type 2) Goto-Kakizaki ratA Global Approach for Quantitative Super Resolution and Electron Microscopy on Cryo and Epoxy Sections Using Self-labeling Protein TagsHumoral autoimmunity against the extracellular domain of the neuroendocrine autoantigen IA-2 heightens the risk of type 1 diabetesBlood Glucose Homeostasis in the Course of Partial Pancreatectomy--Evidence for Surgically Reversible Diabetes Induced by Cholestasis.SUMO downregulates GLP-1-stimulated cAMP generation and insulin secretionThe pancreatic beta cell surface proteome.Novel prokaryotic expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2), its characterization and immunodiagnostic application.IA-2 modulates dopamine secretion in PC12 cells.Neonatal β cell development in mice and humans is regulated by calcineurin/NFATImmunohistochemical analysis of IA-2 family of protein tyrosine phosphatases in rat gastrointestinal endocrine cells.Increase in Insulin Secretion Induced by Panax ginseng Berry Extracts Contributes to the Amelioration of Hyperglycemia in Streptozotocininduced Diabetic Mice.Dense-core vesicle proteins IA-2 and IA-2{beta} affect renin synthesis and secretion through the {beta}-adrenergic pathway.Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growthMinireview: Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansionSmall cell lung cancer growth is inhibited by miR-342 through its effect of the target gene IA-2Signaling from the secretory granule to the nucleus.Erythropoietin receptor response circuitsIslet Autoantibodies.Islet Autoantibody Analysis: Radioimmunoassays.Involvement of P2X receptors in the regulation of insulin secretion, proliferation and survival in mouse pancreatic β-cells.Luminal interaction of phogrin with carboxypeptidase E for effective targeting to secretory granules.Fluorocarbons Enhance Intracellular Delivery of Short STAT3-sensors and Enable Specific Imaging.Identification of Unique Antigenic Determinants in the Amino Terminus of IA-2 (ICA512) in Childhood and Adult Autoimmune Diabetes: New Biomarker Development.The pseudophosphatase phogrin enables glucose-stimulated insulin signaling in pancreatic β cells.
P2860
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P2860
ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs
description
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2008
@ast
im Januar 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/01/15)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/01/15)
@nl
наукова стаття, опублікована в січні 2008
@uk
name
ICA512 signaling enhances panc ...... lating cyclins D through STATs
@ast
ICA512 signaling enhances panc ...... lating cyclins D through STATs
@en
ICA512 signaling enhances panc ...... lating cyclins D through STATs
@nl
type
label
ICA512 signaling enhances panc ...... lating cyclins D through STATs
@ast
ICA512 signaling enhances panc ...... lating cyclins D through STATs
@en
ICA512 signaling enhances panc ...... lating cyclins D through STATs
@nl
prefLabel
ICA512 signaling enhances panc ...... lating cyclins D through STATs
@ast
ICA512 signaling enhances panc ...... lating cyclins D through STATs
@en
ICA512 signaling enhances panc ...... lating cyclins D through STATs
@nl
P2093
P2860
P921
P3181
P356
P1476
ICA512 signaling enhances panc ...... lating cyclins D through STATs
@en
P2093
Florian Ehehalt
Hassan Mziaut
Hendrik Bergert
Katja Erdmann
Klaus-Peter Knoch
Michele Solimena
Mirko Trajkovski
Stephan Kersting
Wan-Hung Fan
P2860
P304
P3181
P356
10.1073/PNAS.0710931105
P407
P577
2008-01-15T00:00:00Z