Expression and characterization of the human mitochondrial leucyl-tRNA synthetase
about
An archaebacteria-derived glutamyl-tRNA synthetase and tRNA pair for unnatural amino acid mutagenesis of proteins in Escherichia coliA single residue in leucyl-tRNA synthetase affecting amino acid specificity and tRNA aminoacylationPost-transcriptional nucleotide modification and alternative folding of RNAtRNA biology in mitochondriaHuman mitochondrial leucyl-tRNA synthetase corrects mitochondrial dysfunctions due to the tRNALeu(UUR) A3243G mutation, associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symptoms and diabetesSearch for characteristic structural features of mammalian mitochondrial tRNAs.Identification of genes potentially involved in disease transformation of CML.HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG.Overexpression of human mitochondrial valyl tRNA synthetase can partially restore levels of cognate mt-tRNAVal carrying the pathogenic C25U mutationMutations in LARS2, encoding mitochondrial leucyl-tRNA synthetase, lead to premature ovarian failure and hearing loss in Perrault syndrome.The pathogenic U3271C human mitochondrial tRNA(Leu(UUR)) mutation disrupts a fragile anticodon stem.Identity elements for the aminoacylation of metazoan mitochondrial tRNA(Arg) have been widely conserved throughout evolution and ensure the fidelity of the AGR codon reassignment.The isolated carboxy-terminal domain of human mitochondrial leucyl-tRNA synthetase rescues the pathological phenotype of mitochondrial tRNA mutations in human cellsHuman mitochondrial leucyl tRNA synthetase can suppress non cognate pathogenic mt-tRNA mutationsLoss of a primordial identity element for a mammalian mitochondrial aminoacylation system.leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate_R-HSA-379726
P2860
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P2860
Expression and characterization of the human mitochondrial leucyl-tRNA synthetase
description
2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2000
@ast
im Februar 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/02/29)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/02/29)
@nl
наукова стаття, опублікована в лютому 2000
@uk
مقالة علمية (نشرت في 29-2-2000)
@ar
name
Expression and characterization of the human mitochondrial leucyl-tRNA synthetase
@ast
Expression and characterization of the human mitochondrial leucyl-tRNA synthetase
@en
Expression and characterization of the human mitochondrial leucyl-tRNA synthetase
@nl
type
label
Expression and characterization of the human mitochondrial leucyl-tRNA synthetase
@ast
Expression and characterization of the human mitochondrial leucyl-tRNA synthetase
@en
Expression and characterization of the human mitochondrial leucyl-tRNA synthetase
@nl
prefLabel
Expression and characterization of the human mitochondrial leucyl-tRNA synthetase
@ast
Expression and characterization of the human mitochondrial leucyl-tRNA synthetase
@en
Expression and characterization of the human mitochondrial leucyl-tRNA synthetase
@nl
P2093
P921
P1476
Expression and characterization of the human mitochondrial leucyl-tRNA synthetase
@en
P2093
J. M. Bullard
L. L. Spremulli
P304
P356
10.1016/S0167-4781(99)00240-7
P407
P577
2000-02-29T00:00:00Z