Identification of a novel human nicotinamide mononucleotide adenylyltransferase
about
Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activityEndogenous Nmnat2 is an essential survival factor for maintenance of healthy axonsEnzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promotersSubcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoformsCharacterization of human brain nicotinamide 5'-mononucleotide adenylyltransferase-2 and expression in human pancreasStructural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesisMutations in NMNAT1 cause Leber congenital amaurosis with early-onset severe macular and optic atrophyExpression, localization, and biochemical characterization of nicotinamide mononucleotide adenylyltransferase 2The slow Wallerian degeneration protein, WldS, binds directly to VCP/p97 and partially redistributes it within the nucleus.Overexpression of Wld(S) or Nmnat2 in mauthner cells by single-cell electroporation delays axon degeneration in live zebrafish.The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways.Isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferasesNew facets in the regulation of gene expression by ADP-ribosylation and poly(ADP-ribose) polymerases.Wallerian degeneration, wld(s), and nmnat.Nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) regulates axon integrity in the mouse embryo.Simultaneous single-sample determination of NMNAT isozyme activities in mouse tissues.Metabolic profiling of alternative NAD biosynthetic routes in mouse tissuesNicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotideCREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathyRegulation of poly(ADP-ribose) polymerase-1-dependent gene expression through promoter-directed recruitment of a nuclear NAD+ synthase.Nmnat3 Is Dispensable in Mitochondrial NAD Level Maintenance In Vivo.SIRT3 regulates cell proliferation and apoptosis related to energy metabolism in non-small cell lung cancer cells through deacetylation of NMNAT2The role of NAD biosynthesis in plant development and stress responses.NAD and axon degeneration: from the Wlds gene to neurochemistry.PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes.Wld(S), Nmnats and axon degeneration--progress in the past two decades.NAD+ metabolism and oxidative stress: the golden nucleotide on a crown of thorns.Diversification of NAD biological role: the importance of location.Mitochondrial dysfunction and NAD(+) metabolism alterations in the pathophysiology of acute brain injury.NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism.Nicotinamide mononucleotide adenylyltransferase2 overexpression enhances colorectal cancer cell-kill by Tiazofurin.Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells.Homology modeling and deletion mutants of human nicotinamide mononucleotide adenylyltransferase isozyme 2: new insights on structure and function relationship.Weak coupling of ATP hydrolysis to the chemical equilibrium of human nicotinamide phosphoribosyltransferase.Emissive synthetic cofactors: enzymatic interconversions of tzA analogues of ATP, NAD+, NADH, NADP+ and NADPH.NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAADNMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+Lack of nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2): consequences for mouse bladder development and function.Structural insights into Plasmodium falciparum nicotinamide mononucleotide adenylyltransferase: oligomeric assembly
P2860
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P2860
Identification of a novel human nicotinamide mononucleotide adenylyltransferase
description
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
im Oktober 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/10/04)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/10/04)
@nl
наукова стаття, опублікована в жовтні 2002
@uk
مقالة علمية (نشرت في 4-10-2002)
@ar
name
Identification of a novel human nicotinamide mononucleotide adenylyltransferase
@ast
Identification of a novel human nicotinamide mononucleotide adenylyltransferase
@en
Identification of a novel human nicotinamide mononucleotide adenylyltransferase
@nl
type
label
Identification of a novel human nicotinamide mononucleotide adenylyltransferase
@ast
Identification of a novel human nicotinamide mononucleotide adenylyltransferase
@en
Identification of a novel human nicotinamide mononucleotide adenylyltransferase
@nl
prefLabel
Identification of a novel human nicotinamide mononucleotide adenylyltransferase
@ast
Identification of a novel human nicotinamide mononucleotide adenylyltransferase
@en
Identification of a novel human nicotinamide mononucleotide adenylyltransferase
@nl
P2093
P1476
Identification of a novel human nicotinamide mononucleotide adenylyltransferase
@en
P2093
Francesca Mazzola
Giulio Magni
Leonardo Sorci
Monica Emanuelli
Nadia Raffaelli
P304
P356
10.1016/S0006-291X(02)02285-4
P407
P50
P577
2002-10-01T00:00:00Z