Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors
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Src homology-2 domain-containing protein tyrosine phosphatase (SHP) 2 and p38 regulate the expression of chemokine CXCL8 in human astrocytesBivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative mannerA novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activationStructural and functional consequences of tyrosine phosphorylation in the LRP1 cytoplasmic domainDissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domainsPhosphoproteomics of collagen receptor networks reveals SHP-2 phosphorylation downstream of wild-type DDR2 and its lung cancer mutantsSimulating EGFR-ERK signaling control by scaffold proteins KSR and MP1 reveals differential ligand-sensitivity co-regulated by Cbl-CIN85 and endophilinSHP-2 is a novel target of Abl kinases during cell proliferation.Profiling of the renal kinome: a novel tool to identify protein kinases involved in angiotensin II-dependent hypertensive renal damageThe docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse developmentMouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutationSUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1.Allostery mediates ligand binding to Grb2 adaptor in a mutually exclusive manner.Assembly of the Sos1-Grb2-Gab1 ternary signaling complex is under allosteric controlTyrosine phosphatases Shp1 and Shp2 have unique and opposing roles in oligodendrocyte development.SHP-2 phosphatase activity is required for PECAM-1-dependent cell motility.SHP2 mediates the localized activation of Fyn downstream of the α6β4 integrin to promote carcinoma invasion.Shp2 activates Fyn and Ras to regulate RBL-2H3 mast cell activation following FcεRI aggregation.Critical role of SHP2 (PTPN11) signaling in germinal center-derived lymphoma.A Novel Phosphopeptide Microarray Based Interactome Map in Breast Cancer Cells Reveals Phosphoprotein-GRB2 Cell Signaling Networks.Binding of the cSH3 domain of Grb2 adaptor to two distinct RXXK motifs within Gab1 docker employs differential mechanisms.Host response during Yersinia pestis infection of human bronchial epithelial cells involves negative regulation of autophagy and suggests a modulation of survival-related and cellular growth pathways.Phosphatase specificity and pathway insulation in signaling networks.SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesisInhibition of Shp2 suppresses mutant EGFR-induced lung tumors in transgenic mouse model of lung adenocarcinoma.Structure-based kinetic models of modular signaling protein function: focus on Shp2.Multivalent binding and facilitated diffusion account for the formation of the Grb2-Sos1 signaling complex in a cooperative manner.Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma development.Abl regulates smooth muscle cell proliferation by modulating actin dynamics and ERK1/2 activation.PTPN11-associated mutations in the heart: has LEOPARD changed Its RASpots?Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT.The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylationShp2 as a therapeutic target for leptin resistance and obesity.Nf1 mutant mice with p19ARF gene loss develop accelerated hematopoietic disease resembling acute leukemia with a variable phenotype.Early signaling dynamics of the epidermal growth factor receptor.Epithelial tyrosine phosphatase SHP-2 protects against intestinal inflammation in mice.The Src homology 2 domain tyrosine phosphatases SHP-1 and SHP-2: diversified control of cell growth, inflammation, and injury.A tyrosine phosphatase SHP2 gain-of-function mutation enhances malignancy of breast carcinomaM-CSF elevates c-Fos and phospho-C/EBPalpha(S21) via ERK whereas G-CSF stimulates SHP2 phosphorylation in marrow progenitors to contribute to myeloid lineage specification.Protein tyrosine phosphatase SHP2 regulates TGF-β1 production in airway epithelia and asthmatic airway remodeling in mice.
P2860
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P248
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P2860
Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors
description
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2003
@ast
im Oktober 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/10/24)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/10/24)
@nl
наукова стаття, опублікована в жовтні 2003
@uk
name
Tyrosyl phosphorylation of Shp ...... e, but not all, growth factors
@ast
Tyrosyl phosphorylation of Shp ...... e, but not all, growth factors
@en
Tyrosyl phosphorylation of Shp ...... e, but not all, growth factors
@nl
type
label
Tyrosyl phosphorylation of Shp ...... e, but not all, growth factors
@ast
Tyrosyl phosphorylation of Shp ...... e, but not all, growth factors
@en
Tyrosyl phosphorylation of Shp ...... e, but not all, growth factors
@nl
prefLabel
Tyrosyl phosphorylation of Shp ...... e, but not all, growth factors
@ast
Tyrosyl phosphorylation of Shp ...... e, but not all, growth factors
@en
Tyrosyl phosphorylation of Shp ...... e, but not all, growth factors
@nl
P2093
P2860
P921
P356
P1476
Tyrosyl phosphorylation of Shp ...... e, but not all, growth factors
@en
P2093
Benjamin G. Neel
Hiroyuki Nawa
Toshiyuki Araki
P2860
P304
41677–41684
P356
10.1074/JBC.M306461200
P407
P577
2003-10-24T00:00:00Z