SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesis - Wikidata - wikimedia - TriplyDB

SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesis

SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesis

http://www.wikidata.org/entity/Q35182721

about

C/EBPα Dysregulation in AML and ALL Epigenomics of macrophages.IL-3 and CSF-1 interact to promote generation of CD11c+ IL-10-producing macrophages.Granulopoiesis requires increased C/EBPα compared to monopoiesis, correlated with elevated Cebpa in immature G-CSF receptor versus M-CSF receptor expressing cells.Shp2 function in hematopoietic stem cell biology and leukemogenesis.Critical requirement for Stat5 in a mouse model of polycythemia vera.Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis.Human Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFNγ-Like Response The GM-CSF receptor utilizes β-catenin and Tcf4 to specify macrophage lineage differentiation Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2.Systems approach to phagocyte production and activation: neutrophils and monocytes.Mathematical Analysis of Cytokine-Induced Differentiation of Granulocyte-Monocyte Progenitor Cells

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P2860

SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesis

http://www.wikidata.org/entity/Q35182721

description

2011 nî lūn-bûn

@nan

2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

SHP2 tyrosine phosphatase stim ...... okine-dependent granulopoiesis

@ast

SHP2 tyrosine phosphatase stim ...... okine-dependent granulopoiesis

@en

type

label

SHP2 tyrosine phosphatase stim ...... okine-dependent granulopoiesis

@ast

SHP2 tyrosine phosphatase stim ...... okine-dependent granulopoiesis

@en

prefLabel

SHP2 tyrosine phosphatase stim ...... okine-dependent granulopoiesis

@ast

SHP2 tyrosine phosphatase stim ...... okine-dependent granulopoiesis

@en

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BLOOD-2011-01-331157

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P1476

SHP2 tyrosine phosphatase stim ...... okine-dependent granulopoiesis

@en

P2093

Alan D Friedman

http://www.w3.org/2001/XMLSchema#string

Li Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling

Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors

C/EBPalpha deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo

Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha

Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells.

Hematopoietic cytokines can instruct lineage choice.

Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool.

STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils.

C/EBPalpha directs monocytic commitment of primary myeloid progenitors.

Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities

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2266-2274

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scholarly article

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10.1182/BLOOD-2011-01-331157

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8

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2011-07-01T00:00:00Z

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51463318

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21725048

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3162355

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