Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons
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Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons.Strong association between glucocerebrosidase mutations and Parkinson's disease in Sweden.Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models.Gene Therapy: A Promising Approach for Neuroprotection in Parkinson's Disease?Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models.Therapeutic potential of autophagy-enhancing agents in Parkinson's disease.How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease?Adeno-Associated Virus-Based Gene Therapy for CNS Diseases.Gene therapy approaches in the non-human primate model of Parkinson's disease.Glucocerebrosidase Mutations in Parkinson Disease.Discovery, validation and optimization of cerebrospinal fluid biomarkers for use in Parkinson's disease.AAV-PHP.B-Mediated Global-Scale Expression in the Mouse Nervous System Enables GBA1 Gene Therapy for Wide Protection from Synucleinopathy.Animal models of α-synucleinopathy for Parkinson disease drug development.Glucocerebrosidase expression patterns in the non-human primate brain.The lysosomal enzyme alpha-Galactosidase A is deficient in Parkinson's disease brain in association with the pathologic accumulation of alpha-synuclein.Molecular mechanisms of α-synuclein and GBA1 in Parkinson's disease.New developments in genetic rat models of Parkinson's disease.Lysosomal trafficking defects link Parkinson's disease with Gaucher's disease.Silencing of Glucocerebrosidase Gene in Drosophila Enhances the Aggregation of Parkinson's Disease Associated α-Synuclein Mutant A53T and Affects Locomotor Activity.Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain.Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with ageα-Synuclein interacts directly but reversibly with psychosine: implications for α-synucleinopathies
P2860
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P2860
Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons
description
2015 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2015
@ast
im Oktober 2015 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2015/10/01)
@sk
vědecký článek publikovaný v roce 2015
@cs
wetenschappelijk artikel (gepubliceerd op 2015/10/01)
@nl
наукова стаття, опублікована в жовтні 2015
@uk
مقالة علمية نشرت في أكتوبر 2015 حول موضوع: دماغ
@ar
name
Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons
@ast
Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons
@en
Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons
@nl
type
label
Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons
@ast
Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons
@en
Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons
@nl
prefLabel
Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons
@ast
Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons
@en
Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons
@nl
P2093
P50
P921
P3181
P1476
Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons
@en
P2093
Eduardo Perez-Torres
Eilish Brown
Emily M Rocha
Hongmei Cao
Jesse R McLean
Jonathan Beagan
Melissa A Hayes
Sarah C Izen
P304
P3181
P356
10.1016/J.NBD.2015.09.009
P577
2015-10-01T00:00:00Z