Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons.
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Role of microRNAs in the Regulation of α-Synuclein Expression: A Systematic ReviewGene Therapy: A Promising Approach for Neuroprotection in Parkinson's Disease?Chaperoning glucocerebrosidase: a therapeutic strategy for both Gaucher disease and ParkinsonismEndocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins.Gaucher disease: Progress and ongoing challenges.Impulse control disorder, lysosomal malfunction and ATP13A2 insufficiency in Parkinsonism.Crosstalk between sphingolipids and vitamin D3: potential role in the nervous system.The Complicated Relationship between Gaucher Disease and Parkinsonism: Insights from a Rare Disease.Induced Pluripotent Stem Cell Modeling of Gaucher's Disease: What Have We Learned?AAV-PHP.B-Mediated Global-Scale Expression in the Mouse Nervous System Enables GBA1 Gene Therapy for Wide Protection from Synucleinopathy.A Human Neural Crest Stem Cell-Derived Dopaminergic Neuronal Model Recapitulates Biochemical Abnormalities in GBA1 Mutation Carriers.Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease.iPS cells in the study of PD molecular pathogenesis.Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide.Altered Differentiation Potential of Gaucher's Disease iPSC Neuronal Progenitors due to Wnt/β-Catenin Downregulation.Molecular mechanisms of α-synuclein and GBA1 in Parkinson's disease.Ginkgolide K promotes the clearance of A53T mutation alpha-synuclein in SH-SY5Y cells.Effects of ambroxol on the autophagy-lysosome pathway and mitochondria in primary cortical neurons.Lysosomal trafficking defects link Parkinson's disease with Gaucher's disease.Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease.β-Glucocerebrosidase Modulators Promote Dimerization of β-Glucocerebrosidase and Reveal an Allosteric Binding Site.Dysregulation of the autophagic-lysosomal pathway in Gaucher and Parkinson's disease.Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease.Potential Alzheimer's Disease Therapeutics Among Weak Cysteine Protease Inhibitors Exhibit Mechanistic Differences Regarding Extent of Cathepsin B Up-Regulation and Ability to Block Calpain.Is Parkinson's disease a lysosomal disorder?Glucocerebrosidase deficiency promotes protein aggregation through dysregulation of extracellular vesicles
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Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on July 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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Activation of β-Glucocerebrosi ...... on's Patient Midbrain Neurons.
@en
Activation of β-Glucocerebrosi ...... on's Patient Midbrain Neurons.
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type
label
Activation of β-Glucocerebrosi ...... on's Patient Midbrain Neurons.
@en
Activation of β-Glucocerebrosi ...... on's Patient Midbrain Neurons.
@nl
prefLabel
Activation of β-Glucocerebrosi ...... on's Patient Midbrain Neurons.
@en
Activation of β-Glucocerebrosi ...... on's Patient Midbrain Neurons.
@nl
P2093
P2860
P50
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P1476
Activation of β-Glucocerebrosi ...... son's Patient Midbrain Neurons
@en
P2093
Carolyn M Sue
Dimitri Krainc
Joseph R Mazzulli
Juan J Marugan
Lena F Burbulla
Nicholas J Toker
Samarjit Patnaik
Sohee Jeon
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P304
P356
10.1523/JNEUROSCI.0628-16.2016
P407
P577
2016-07-01T00:00:00Z