Synucleins are a novel class of substrates for G protein-coupled receptor kinases
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G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosisParkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer modelPolo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivoMisfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathiesGRK2: multiple roles beyond G protein-coupled receptor desensitizationGeneration of choline for acetylcholine synthesis by phospholipase D isoformsPhysicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's diseaseImpaired c-Fos and polo-like kinase 2 induction in the limbic system of fear-conditioned α-synuclein transgenic miceThe phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's diseaseGamma-synuclein as a marker of retinal ganglion cellsA G protein-coupled receptor kinase induces Xenopus oocyte maturationPhosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactionsAssessing the subcellular dynamics of alpha-synuclein using photoactivation microscopy.alpha-Synuclein affects the MAPK pathway and accelerates cell death.Phosphorylation of synucleins by members of the Polo-like kinase family.G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells.Transgenic mice expressing S129 phosphorylation mutations in α-synuclein.G-protein-coupled-receptor kinases mediate TNFα-induced NFκB signalling via direct interaction with and phosphorylation of IκBα.Parkinson's disease-implicated kinases in the brain; insights into disease pathogenesis.Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates.Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo.The role of n-3 polyunsaturated fatty acids in brain: modulation of rat brain gene expression by dietary n-3 fatty acidsSpecificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.Gamma synuclein: subcellular localization in neuronal and non-neuronal cells and effect on signal transduction.Phosphorylated α-synuclein in Parkinson's disease: correlation depends on disease severityLewy bodies.Iron and Parkinson's disease.Glial cell inclusions and the pathogenesis of neurodegenerative diseasesEvaluating the relationship between amyloid-β and α-synuclein phosphorylated at Ser129 in dementia with Lewy bodies and Parkinson's disease.Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation.G-protein coupled receptor kinase 5 mediates lipopolysaccharide-induced NFκB activation in primary macrophages and modulates inflammation in vivo in mice.Alpha-synuclein function and dysfunction on cellular membranes.SMG1 identified as a regulator of Parkinson's disease-associated alpha-synuclein through siRNA screening.G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivoG protein-coupled receptor kinases: more than just kinases and not only for GPCRsα-Synuclein stimulates a dopamine transporter-dependent chloride current and modulates the activity of the transporter.Monitoring of phosphorylated peptides by radioactive assay and matrix-assisted laser desorption-ionization time-of-flight mass spectrometry.
P2860
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P2860
Synucleins are a novel class of substrates for G protein-coupled receptor kinases
description
2000 nî lūn-bûn
@nan
2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Synucleins are a novel class of substrates for G protein-coupled receptor kinases
@ast
Synucleins are a novel class of substrates for G protein-coupled receptor kinases
@en
Synucleins are a novel class of substrates for G protein-coupled receptor kinases
@nl
type
label
Synucleins are a novel class of substrates for G protein-coupled receptor kinases
@ast
Synucleins are a novel class of substrates for G protein-coupled receptor kinases
@en
Synucleins are a novel class of substrates for G protein-coupled receptor kinases
@nl
prefLabel
Synucleins are a novel class of substrates for G protein-coupled receptor kinases
@ast
Synucleins are a novel class of substrates for G protein-coupled receptor kinases
@en
Synucleins are a novel class of substrates for G protein-coupled receptor kinases
@nl
P2093
P3181
P356
P1476
Synucleins are a novel class of substrates for G protein-coupled receptor kinases
@en
P2093
A J Morris
A N Pronin
A Surguchov
J L Benovic
P304
P3181
P356
10.1074/JBC.M003542200
P407
P577
2000-08-25T00:00:00Z