Molecular cloning, expression, and chromosomal localization of a ubiquitously expressed human 6-phosphofructo-2-kinase/ fructose-2, 6-bisphosphatase gene (PFKFB3)
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysisMechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cellsMolecular basis of the fructose-2,6-bisphosphatase reaction of PFKFB3: Transition state and the C-terminal functionRegulation of ubiquitous 6-phosphofructo-2-kinase by the ubiquitin-proteasome proteolytic pathway during myogenic C2C12 cell differentiationHypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effectProgestins activate 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in breast cancer cells6-Phosphofructo-2-kinase (pfkfb3) gene promoter contains hypoxia-inducible factor-1 binding sites necessary for transactivation in response to hypoxiaOverexpression of fructose 2,6-bisphosphatase decreases glycolysis and delays cell cycle progressionDifferentiation stage-specific requirement in hypoxia-inducible factor-1alpha-regulated glycolytic pathway during murine B cell development in bone marrow.The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase.PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli.Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha activation.Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegenerationAndrogen stimulates glycolysis for de novo lipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 in prostate cancer cells.Ras transformation requires metabolic control by 6-phosphofructo-2-kinase.Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family (PFKFB-1-4) expression in vivo.The molecular basis of targeting PFKFB3 as a therapeutic strategy against cancer.UCP2 overexpression enhanced glycolysis via activation of PFKFB2 during skin cell transformation.Aripiprazole increases NADPH level in PC12 cells: the role of NADPH oxidase.TGF-β1 targets Smad, p38 MAPK, and PI3K/Akt signaling pathways to induce PFKFB3 gene expression and glycolysis in glioblastoma cells.Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway.LOH on 10p14-p15 targets the PFKFB3 gene locus in human glioblastomas.Akt mediates TIGAR induction in HeLa cells following PFKFB3 inhibition.RNAi screening in glioma stem-like cells identifies PFKFB4 as a key molecule important for cancer cell survival.Fructose 2,6-Bisphosphate in Cancer Cell Metabolism
P2860
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P2860
Molecular cloning, expression, and chromosomal localization of a ubiquitously expressed human 6-phosphofructo-2-kinase/ fructose-2, 6-bisphosphatase gene (PFKFB3)
description
1998 nî lūn-bûn
@nan
1998 թուականին հրատարակուած գիտական յօդուած
@hyw
1998 թվականին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Molecular cloning, expression, ...... 6-bisphosphatase gene (PFKFB3)
@ast
Molecular cloning, expression, ...... 6-bisphosphatase gene (PFKFB3)
@en
Molecular cloning, expression, ...... 6-bisphosphatase gene (PFKFB3)
@nl
type
label
Molecular cloning, expression, ...... 6-bisphosphatase gene (PFKFB3)
@ast
Molecular cloning, expression, ...... 6-bisphosphatase gene (PFKFB3)
@en
Molecular cloning, expression, ...... 6-bisphosphatase gene (PFKFB3)
@nl
prefLabel
Molecular cloning, expression, ...... 6-bisphosphatase gene (PFKFB3)
@ast
Molecular cloning, expression, ...... 6-bisphosphatase gene (PFKFB3)
@en
Molecular cloning, expression, ...... 6-bisphosphatase gene (PFKFB3)
@nl
P2093
P50
P356
P1476
Molecular cloning, expression, ...... 6-bisphosphatase gene (PFKFB3)
@en
P2093
P304
P356
10.1159/000015181
P407
P577
1998-01-01T00:00:00Z