A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation
about
Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase CStructure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formationNucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activityComprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein networkThe cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase CzetaMEK5, a new target of the atypical protein kinase C isoforms in mitogenic signalingIdentification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivatorProtein kinase C iota: human oncogene, prognostic marker and therapeutic targetJunctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctionsExtracellular and Intracellular Signaling for Neuronal PolarityCytotoxic and DNA-targeted therapy in urothelial cancer: have we squeezed the lemon enough?Rho GTPases in cell biologyAKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formationInteraction codes within the family of mammalian Phox and Bem1p domain-containing proteinsDown-regulated expression of atypical PKC-binding domain deleted asip isoforms in human hepatocellular carcinomasMulti-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion moleculeJEAP, a novel component of tight junctions in exocrine cellsIdentification of the region in Cdc42 that confers the binding specificity to activated Cdc42-associated kinaseTight-junction protein zonula occludens 2 is a target of phosphorylation by protein kinase CProtein kinase Czeta mediates insulin-induced glucose transport through actin remodeling in L6 muscle cellsPar-3-mediated junctional localization of the lipid phosphatase PTEN is required for cell polarity establishmentCdx2 regulates endo-lysosomal function and epithelial cell polarityRHO-GTPases and cancerThe interdependence of the Rho GTPases and apicobasal cell polarity.Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesisInteraction of PAR-6 with CDC-42 is required for maintenance but not establishment of PAR asymmetry in C. elegansFractionation of the epithelial apical junctional complex: reassessment of protein distributions in different substructuresSignaling involved in neurite outgrowth of postnatally born subventricular zone neurons in vitro.Structural properties and mechanisms that govern association of C kinase adapter 1 with protein kinase C3 and the cell periphery.Binding to PKC-3, but not to PAR-3 or to a conventional PDZ domain ligand, is required for PAR-6 function in C. elegansTissue polarity-dependent control of mammary epithelial homeostasis and cancer development: an epigenetic perspective.Cdc42-dependent modulation of tight junctions and membrane protein traffic in polarized Madin-Darby canine kidney cellsThe insert region of Rac1 is essential for membrane ruffling but not cellular transformation.Establishment of epithelial polarity--GEF who's minding the GAP?The ups and downs of life in an epithelium.The organization of tight junctions in epithelia: implications for mammary gland biology and breast tumorigenesisThe polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer.The atypical protein kinase Cs. Functional specificity mediated by specific protein adapters
P2860
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P2860
A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation
description
2000 nî lūn-bûn
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2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
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2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
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2000年论文
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name
A human homolog of the C. eleg ...... naling and cell transformation
@ast
A human homolog of the C. eleg ...... naling and cell transformation
@en
A human homolog of the C. eleg ...... naling and cell transformation
@nl
type
label
A human homolog of the C. eleg ...... naling and cell transformation
@ast
A human homolog of the C. eleg ...... naling and cell transformation
@en
A human homolog of the C. eleg ...... naling and cell transformation
@nl
prefLabel
A human homolog of the C. eleg ...... naling and cell transformation
@ast
A human homolog of the C. eleg ...... naling and cell transformation
@en
A human homolog of the C. eleg ...... naling and cell transformation
@nl
P2093
P1433
P1476
A human homolog of the C. eleg ...... naling and cell transformation
@en
P2093
P304
P356
10.1016/S0960-9822(00)00535-2
P407
P577
2000-06-15T00:00:00Z