Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesis - Wikidata - wikimedia - TriplyDB

Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesis

Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesis

http://www.wikidata.org/entity/Q30499299

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Spindle orientation in mammalian cerebral cortical development Polarity in mammalian epithelial morphogenesis Emerging role of cell polarity proteins in breast cancer progression and metastasis Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling.Huntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKC Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes Cdc42 in oncogenic transformation, invasion, and tumorigenesis Phenotypical analysis of atypical PKCs in vivo function display a compensatory system at mouse embryonic day 7.5 Merlin/ERM proteins establish cortical asymmetry and centrosome position.Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis Influence of cell polarity on early development of the sea urchin embryo The LKB1 tumor suppressor controls spindle orientation and localization of activated AMPK in mitotic epithelial cells.Epithelial cell differentiation regulated by MicroRNA-200a in mammary glands.SOS1 and Ras regulate epithelial tight junction formation in the human airway through EMP1.Oncogenic suppression of apoptosis uncovers a Rac1/JNK proliferation pathway activated by loss of Par3.The Rho GTPase Cdc42 is required for primary mammary epithelial cell morphogenesis in vitro.Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice.aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation.Inhibition of protein kinase C by isojacareubin suppresses hepatocellular carcinoma metastasis and induces apoptosis in vitro and in vivo.BMP4 depletion by miR-200 inhibits tumorigenesis and metastasis of lung adenocarcinoma cells.K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc.Nonredundant roles of cytoplasmic β- and γ-actin isoforms in regulation of epithelial apical junctions The Par complex and integrins direct asymmetric cell division in adult intestinal stem cells.Functional comparison of protein domains within aPKCs involved in nucleocytoplasmic shuttling.Cell Fate Decision Making through Oriented Cell Division.The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42 Thyroid bud morphogenesis requires CDC42- and SHROOM3-dependent apical constriction.aPKCλ controls epidermal homeostasis and stem cell fate through regulation of division orientation Breaking the epithelial polarity barrier in cancer: the strange case of LKB1/PAR-4 Atypical protein kinase Cλ is critical for growth factor receptor-induced dorsal ruffle turnover and cell migration PTEN phosphatase-independent maintenance of glandular morphology in a predictive colorectal cancer model system.Cdc42 coordinates proliferation, polarity, migration, and differentiation of small intestinal epithelial cells in mice.Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids.Vitamin D3 suppresses morphological evolution of the cribriform cancerous phenotype Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms.Epithelial cell polarity, stem cells and cancer.An oblique view on the role of spindle orientation in vertebrate neurogenesis.Cell polarity as a regulator of cancer cell behavior plasticity.Microtubule plus-ends within a mitotic cell are 'moving platforms' with anchoring, signalling and force-coupling roles.

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Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesis

http://www.wikidata.org/entity/Q30499299

description

2011 nî lūn-bûn

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2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի փետրվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

@zh-hant

2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Par6B and atypical PKC regulat ...... uring epithelial morphogenesis

@ast

Par6B and atypical PKC regulat ...... uring epithelial morphogenesis

@en

type

label

Par6B and atypical PKC regulat ...... uring epithelial morphogenesis

@ast

Par6B and atypical PKC regulat ...... uring epithelial morphogenesis

@en

prefLabel

Par6B and atypical PKC regulat ...... uring epithelial morphogenesis

@ast

Par6B and atypical PKC regulat ...... uring epithelial morphogenesis

@en

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Journal of Biological Chemistry

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Par6B and atypical PKC regulat ...... uring epithelial morphogenesis

@en

P2093

Alan Hall

http://www.w3.org/2001/XMLSchema#string

Dan Jin

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Joanne Durgan

http://www.w3.org/2001/XMLSchema#string

Noriko Kaji

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P2860

The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures

Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C

Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6

The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis.

Protein kinase C iota: human oncogene, prognostic marker and therapeutic target

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation

A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation

A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells

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