A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE
about
Main roads to melanomaCyclic stretch stimulates vascular smooth muscle cell alignment by redox-dependent activation of Notch3Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain.Notch signaling induces rapid degradation of achaete-scute homolog 1.Conserved signal peptide of Notch3 inhibits interaction with proteasomeThe adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathwayTspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammalsMT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell developmentEvidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activationLow density lipoprotein receptor-related protein-1 (LRP1) regulates thrombospondin-2 (TSP2) enhancement of Notch3 signalingThe heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality.SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway.Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysisp300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitroA CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling.Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in DrosophilaThrombospondin 2 potentiates notch3/jagged1 signalingThe cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreadingThe Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretaseIdentification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1Does Notch play a tumor suppressor role across diverse squamous cell carcinomas?A Disintegrin and Metalloprotease (ADAM): Historical Overview of Their FunctionsRecent advances in the field of anti-cancer immunotherapyTrafficking regulation of proteins in Alzheimer's diseaseTargeting the Notch signaling pathway in cancer therapeuticsTips, stalks, tubes: notch-mediated cell fate determination and mechanisms of tubulogenesis during angiogenesisToward the structure of presenilin/γ-secretase and presenilin homologsWound healing and cancer stem cells: inflammation as a driver of treatment resistance in breast cancerThe Notch pathway is important in maintaining the cancer stem cell population in pancreatic cancerForce-induced unfolding simulations of the human Notch1 negative regulatory region: possible roles of the heterodimerization domain in mechanosensingThe Wnt receptor Frizzled-4 modulates ADAM13 metalloprotease activityStructural basis for autoinhibition of NotchStructure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALLEffects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexesConformational Locking upon Cooperative Assembly of Notch Transcription ComplexesFringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligandsNotch ligand delta-like1: X-ray crystal structure and binding affinity
P2860
Q21245465-E6161B31-5488-40C8-90D8-3A404FEAA43FQ23914856-F260F343-3F36-4765-A92C-534590BDE3B5Q24292244-F3DB1EFA-F4E6-44F5-83B6-5C6C8237A7F6Q24293622-70CFA445-E702-4E63-80B0-76D2AD97CAC0Q24296735-AB981CE7-A7B8-4F53-AB8E-9F5789E0DBEBQ24298942-29D9CE53-DB69-4F8D-BC4D-44EB603F6236Q24301578-32617971-5C98-4256-AF70-9D4B1B629F50Q24302346-FB7EA40A-DE63-4D65-A52A-234A0175E383Q24305944-4E024214-298C-4B0C-9080-62B3004ECC8CQ24306455-D3716CF3-56A4-4EBA-B339-7154737D739EQ24310748-C0197E77-0A7C-4820-AF6D-583BFB9B5B21Q24312809-E0852F93-BF72-41A4-87AE-47BC6E6D4781Q24339579-48E92862-DD52-434B-99D3-5A68758C8CAFQ24534941-AE543C06-25F3-4E21-BE22-12AE85CB68D7Q24537679-F168347E-0F87-4B91-BA71-731ED0EC20ADQ24537773-0F583D17-3F90-4877-AE46-AFBAA57DB786Q24544042-B9EDA838-4447-43D3-9D1F-E6CDA09C4B3DQ24546116-37F910F5-9E14-448F-AA17-BC04F11DD9D0Q24655423-A6774671-8478-479F-8A7E-7DD0DE54F7E5Q24669779-8AFE8C70-1E54-4EAD-B576-D934D63BF945Q24670362-9B6CE80B-C6E0-4F49-A3F3-52FD3A2A87F6Q24670708-94DDDFA4-E962-4CD9-961F-9BFAA29A763AQ26745755-219EB9A4-1441-4A71-9194-63E64E1DC083Q26749364-AC38DD24-C281-43A4-8535-1F3712562B29Q26775602-D8FF6F61-C86E-42A7-9AB1-921201E95262Q26825722-050E0DCD-1564-4B32-A3BE-E1A168554E05Q26863580-E89173BB-8F23-4347-9B14-A48E9F5C8E1FQ26863766-1E089CDF-C717-4BE9-8CCF-9804730E858DQ27002018-A7AC6648-E9B8-4655-844A-FC7B864E6CE2Q27023599-CCE2F576-640F-43E0-9E59-E5DE05583C52Q27315124-B4C9AE59-2BE1-426A-BC2E-BAA0A534658CQ27329590-64CEE287-5FB6-4B82-9763-C85232D52B76Q27341613-F541626D-B7BD-4231-8772-695855DEDE86Q27644319-DDBE320B-016D-469A-9392-FAB6427C4BB8Q27653136-E755FC9D-A0EC-46CA-93E6-46FFC9CC9EF1Q27657133-A627D60E-2F3A-469F-B448-ED28BCC559E2Q27665343-1D0612E1-07BC-4DE3-A942-F1C07313C7CEQ27677210-0C4B461B-4D2F-4A68-90B5-3E9CACBEBDE4Q27683660-FD1185FE-E50D-4676-8DE7-2E0D1AB615DCQ27698064-AED64566-F591-49D0-BA78-6D1F12AC2098
P2860
A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE
description
2000 nî lūn-bûn
@nan
2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
A novel proteolytic cleavage i ...... sintegrin-metalloprotease TACE
@ast
A novel proteolytic cleavage i ...... sintegrin-metalloprotease TACE
@en
A novel proteolytic cleavage i ...... sintegrin-metalloprotease TACE
@nl
type
label
A novel proteolytic cleavage i ...... sintegrin-metalloprotease TACE
@ast
A novel proteolytic cleavage i ...... sintegrin-metalloprotease TACE
@en
A novel proteolytic cleavage i ...... sintegrin-metalloprotease TACE
@nl
prefLabel
A novel proteolytic cleavage i ...... sintegrin-metalloprotease TACE
@ast
A novel proteolytic cleavage i ...... sintegrin-metalloprotease TACE
@en
A novel proteolytic cleavage i ...... sintegrin-metalloprotease TACE
@nl
P2093
P3181
P1433
P1476
A novel proteolytic cleavage i ...... sintegrin-metalloprotease TACE
@en
P2093
J R Doedens
P304
P3181
P356
10.1016/S1097-2765(00)80417-7
P407
P577
2000-02-01T00:00:00Z