Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin
about
Cellular transport and membrane dynamics of the glycine receptorGephyrin, the enigmatic organizer at GABAergic synapsesAsef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation elementThe Intracellular Loop of the Glycine Receptor: It's not all about the SizeRHGF-2 is an essential Rho-1 specific RhoGEF that binds to the multi-PDZ domain scaffold protein MPZ-1 in Caenorhabditis elegansPX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor traffickingRelease of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppressionA conformational switch in collybistin determines the differentiation of inhibitory postsynapsesStimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1Isoform heterogeneity of the human gephyrin gene (GPHN), binding domains to the glycine receptor, and mutation analysis in hyperekplexiaIdentification of a gephyrin-binding motif in the GDP/GTP exchange factor collybistinDistribution of transcripts for the brain-specific GDP/GTP exchange factor collybistin in the developing mouse brainCyclin-dependent kinase 5 is involved in the phosphorylation of gephyrin and clustering of GABAA receptors at inhibitory synapses of hippocampal neuronsIsoforms of kalirin, a neuronal Dbl family member, generated through use of different 5'- and 3'-ends along with an internal translational initiation siteBiochemical characterization of the high affinity binding between the glycine receptor and gephyrinSynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapsesIdentification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neuronsMolecular basis of the γ-aminobutyric acid A receptor α3 subunit interaction with the clustering protein gephyrinThe residence time of GABA(A)Rs at inhibitory synapses is determined by direct binding of the receptor α1 subunit to gephyrinIn vivo transgenic expression of collybistin in neurons of the rat cerebral cortex.Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission.SH3 domain-based phototrapping in living cells reveals Rho family GAP signaling complexesCollybistin splice variants differentially interact with gephyrin and Cdc42 to regulate gephyrin clustering at GABAergic synapses.The role of collybistin in gephyrin clustering at inhibitory synapses: facts and open questions.Differential regulation of the postsynaptic clustering of γ-aminobutyric acid type A (GABAA) receptors by collybistin isoforms.Complex role of collybistin and gephyrin in GABAA receptor clustering.Duplicated gephyrin genes showing distinct tissue distribution and alternative splicing patterns mediate molybdenum cofactor biosynthesis, glycine receptor clustering, and escape behavior in zebrafishGABA(A) receptors and their associated proteins: implications in the etiology and treatment of schizophrenia and related disorders.A balanced chromosomal translocation disrupting ARHGEF9 is associated with epilepsy, anxiety, aggression, and mental retardation.Endosomal Phosphatidylinositol 3-Phosphate Promotes Gephyrin Clustering and GABAergic Neurotransmission at Inhibitory Postsynapses.An E3-ligase-based method for ablating inhibitory synapsesDiversity and phylogeny of gephyrin: tissue-specific splice variants, gene structure, and sequence similarities to molybdenum cofactor-synthesizing and cytoskeleton-associated proteinsMacMARCKS interacts with the metabotropic glutamate receptor type 7 and modulates G protein-mediated constitutive inhibition of calcium channels.Collybistin and gephyrin are novel components of the eukaryotic translation initiation factor 3 complexReceptors, gephyrin and gephyrin-associated proteins: novel insights into the assembly of inhibitory postsynaptic membrane specializations.Understanding the molecular diversity of GABAergic synapses.Splice-specific functions of gephyrin in molybdenum cofactor biosynthesis.Neurotransmitter receptor trafficking and the regulation of synaptic strength.Effects of two elongation factor 1A isoforms on the formation of gephyrin clusters at inhibitory synapses in hippocampal neurons.Deciphering the structural framework of glycine receptor anchoring by gephyrin
P2860
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P2860
Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin
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2000 nî lūn-bûn
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2000年の論文
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2000年論文
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2000年論文
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Collybistin, a newly identifie ...... embrane clustering of gephyrin
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Collybistin, a newly identifie ...... embrane clustering of gephyrin
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Collybistin, a newly identifie ...... embrane clustering of gephyrin
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Collybistin, a newly identifie ...... embrane clustering of gephyrin
@ast
Collybistin, a newly identifie ...... embrane clustering of gephyrin
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Collybistin, a newly identifie ...... embrane clustering of gephyrin
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Collybistin, a newly identifie ...... embrane clustering of gephyrin
@ast
Collybistin, a newly identifie ...... embrane clustering of gephyrin
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Collybistin, a newly identifie ...... embrane clustering of gephyrin
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P2093
P2860
P3181
P356
P1433
P1476
Collybistin, a newly identifie ...... embrane clustering of gephyrin
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P2093
P2860
P2888
P3181
P356
10.1038/71096
P407
P577
2000-01-01T00:00:00Z