Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product
about
Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinasePTTG/securin activates expression of p53 and modulates its functionSecurin is not required for chromosomal stability in human cellsHuman securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosisSecurin enhances the anti-cancer effects of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075) in human colorectal cancer cellsActivation of mitogen-activated protein kinase cascade regulates pituitary tumor-transforming gene transactivation function.Phosphorylation of the mitotic regulator Pds1/securin by Cdc28 is required for efficient nuclear localization of Esp1/separaseEffect of PTTG on endogenous gene expression in HEK 293 cells.Pituitary tumor-transforming gene expression is a prognostic marker for tumor recurrence in squamous cell carcinoma of the head and neck.Mechanisms for pituitary tumorigenesis: the plastic pituitary.Down-regulation of the oncogene PTTG1 via the KLF6 tumor suppressor during induction of myeloid differentiation.The pathogenesis of pituitary tumours.Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone beta receptor inhibits mitotic progression.Glycogen synthase kinase-3beta (GSK3beta) negatively regulates PTTG1/human securin protein stability, and GSK3beta inactivation correlates with securin accumulation in breast tumors.Cloning of Porcine Pituitary Tumor Transforming Gene 1 and Its Expression in Porcine Oocytes and EmbryosPTTG1 expression is associated with hyperproliferative disease and poor prognosis in multiple myeloma.Novel functions of thyroid hormone receptor mutants: beyond nucleus-initiated transcription.PTTG promotes invasion in human breast cancer cell line by upregulating EMMPRIN via FAK/Akt/mTOR signalingPTTG: an important target gene for ovarian cancer therapy.Securin is a target of the UV response pathway in mammalian cellsControl of alpha subunit of eukaryotic translation initiation factor 2 (eIF2 alpha) phosphorylation by the human papillomavirus type 18 E6 oncoprotein: implications for eIF2 alpha-dependent gene expression and cell death.Pituitary tumor-transforming gene and its binding factor in endocrine cancer.Securin (hPTTG1) expression is regulated by beta-catenin/TCF in human colorectal carcinomaPTTG1/securin modulates microtubule nucleation and cell migration.Paclitaxel sensitivity of breast cancer cells requires efficient mitotic arrest and disruption of Bcl-xL/Bak interaction.Regulation of angiogenesis and invasion by human Pituitary tumor transforming gene (PTTG) through increased expression and secretion of matrix metalloproteinase-2 (MMP-2).Protein phosphatase 2A stabilizes human securin, whose phosphorylated forms are degraded via the SCF ubiquitin ligase.Securin a new role for itself.Human full-length Securin is a natively unfolded protein.DNA damage-induced inhibition of securin expression is mediated by p53.Expression and function of pituitary tumour transforming gene for T-lymphocyte activation.High expression of the sister-chromatid separation regulator and proto-oncogene hSecurin occurs in a subset of myeloid leukaemias but is not implicated in the pathogenesis of aneuploidy.
P2860
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P2860
Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product
description
2000 nî lūn-bûn
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2000 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2000 թվականի հունվարին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
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name
Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product
@ast
Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product
@en
Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product
@nl
type
label
Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product
@ast
Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product
@en
Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product
@nl
prefLabel
Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product
@ast
Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product
@en
Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product
@nl
P2093
P3181
P356
P1433
P1476
Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product
@en
P2093
A Domínguez
F Ramos-Morales
J A Pintor-Toro
M C Multon
M Tortolero
P2888
P3181
P356
10.1038/SJ.ONC.1203320
P407
P577
2000-01-20T00:00:00Z
P6179
1017601813