Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis - Wikidata - wikimedia - TriplyDB

Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis

Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis

http://www.wikidata.org/entity/Q28204629

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The PTTG1-binding factor (PBF/PTTG1IP) regulates p53 activity in thyroid cells The emerging role of pituitary tumor transforming gene in tumorigenesis Acromegaly pathogenesis and treatment Transcriptional patterns, biomarkers and pathways characterizing nasopharyngeal carcinoma of Southern China PTTG/securin activates expression of p53 and modulates its function The influence of the pituitary tumor transforming gene-1 (PTTG-1) on survival of patients with small cell lung cancer and non-small cell lung cancer.PTTG1 attenuates drug-induced cellular senescence A molecular signature of metastasis in primary solid tumors Critical differences between isoforms of securin reveal mechanisms of separase regulation Mechanisms for pituitary tumorigenesis: the plastic pituitary.PTTG1 overexpression in adrenocortical cancer is associated with poor survival and represents a potential therapeutic target Cdc20 and securin overexpression predict short-term breast cancer survival.Mitotic chromosomal instability and cancer: mouse modelling of the human disease.Overexpression of the pituitary tumor transforming gene induces p53-dependent senescence through activating DNA damage response pathway in normal human fibroblasts.Loss of cytoplasmic CDK1 predicts poor survival in human lung cancer and confers chemotherapeutic resistance The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function.Gene expression profiling of microdissected pancreatic ductal carcinomas using high-density DNA microarrays High expression of pituitary tumor-transforming gene-1 predicts poor prognosis in clear cell renal cell carcinoma.Glycogen synthase kinase-3beta (GSK3beta) negatively regulates PTTG1/human securin protein stability, and GSK3beta inactivation correlates with securin accumulation in breast tumors.Murine candidate bleomycin induced pulmonary fibrosis susceptibility genes identified by gene expression and sequence analysis of linkage regions FoxM1 transactivates PTTG1 and promotes colorectal cancer cell migration and invasion Evidence for cooperative transforming activity of the human pituitary tumor transforming gene and human T-cell leukemia virus type 1 Tax.Overexpressed hPTTG1 promotes breast cancer cell invasion and metastasis by regulating GEF-H1/RhoA signalling PTTG1 expression is associated with hyperproliferative disease and poor prognosis in multiple myeloma.The PTTG1-targeting miRNAs miR-329, miR-300, miR-381, and miR-655 inhibit pituitary tumor cell tumorigenesis and are involved in a p53/PTTG1 regulation feedback loop.Proliferation marker securin identifies favourable outcome in invasive ductal breast cancer.p21(Cip1) restrains pituitary tumor growth.Securin is a target of the UV response pathway in mammalian cells Master regulators of FGFR2 signalling and breast cancer risk Diminished pancreatic beta-cell mass in securin-null mice is caused by beta-cell apoptosis and senescence A small-molecule inhibitor targeting the mitotic spindle checkpoint impairs the growth of uterine leiomyosarcoma.E2F1 induces pituitary tumor transforming gene (PTTG1) expression in human pituitary tumors Combining fisetin and ionizing radiation suppresses the growth of mammalian colorectal cancers in xenograft tumor models.Key signaling molecules in pituitary tumors.Regulation of p53--insights into a complex process.PTTG1 regulated by miR-146a-3p promotes bladder cancer migration, invasion, metastasis and growth.Isolation and characterization of novel pituitary tumor related genes: a cDNA representational difference approach.Cohesin: a regulator of genome integrity and gene expression.Pituitary tumor-transforming gene and its binding factor in endocrine cancer.Viral takeover of the host ubiquitin system.

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P2860

Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis

http://www.wikidata.org/entity/Q28204629

description

2002 nî lūn-bûn

@nan

2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

@zh-hant

2002年論文

@zh-hk

2002年論文

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2002年論文

@zh-tw

2002年论文

@wuu

name

Human securin interacts with p ...... ptional activity and apoptosis

@ast

Human securin interacts with p ...... ptional activity and apoptosis

@en

Human securin interacts with p ...... ptional activity and apoptosis

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type

label

Human securin interacts with p ...... ptional activity and apoptosis

@ast

Human securin interacts with p ...... ptional activity and apoptosis

@en

Human securin interacts with p ...... ptional activity and apoptosis

@nl

prefLabel

Human securin interacts with p ...... ptional activity and apoptosis

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Human securin interacts with p ...... ptional activity and apoptosis

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Human securin interacts with p ...... ptional activity and apoptosis

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P1433

Nature Genetics

P1476

Human securin interacts with p ...... ptional activity and apoptosis

@en

P2093

Agueda Espina

http://www.w3.org/2001/XMLSchema#string

Augusto Silva

http://www.w3.org/2001/XMLSchema#string

Carmen Arias

http://www.w3.org/2001/XMLSchema#string

Francisco Ramos-Morales

http://www.w3.org/2001/XMLSchema#string

Icíar Lázaro

http://www.w3.org/2001/XMLSchema#string

José A Pintor-Toro

http://www.w3.org/2001/XMLSchema#string

Rosa Luna

http://www.w3.org/2001/XMLSchema#string

P2860

The Hallmarks of Cancer

Compromised HOXA5 function can limit p53 expression in human breast tumours

Mdm2 promotes the rapid degradation of p53

Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase

p53, the cellular gatekeeper for growth and division

WAF1, a potential mediator of p53 tumor suppression

Genetic instabilities in human cancers

Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis

Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product

Securin is required for chromosomal stability in human cells

P2888

P304

306-11

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scholarly article

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10.1038/NG997

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P433

2

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P478

32

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Francisco Romero

María Tortolero

P577

2002-10-01T00:00:00Z

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P5875

11102515

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1025425348

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P698

12355087

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P921

apoptotic process