Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms
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Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptorMultifaceted role of β-arrestins in inflammation and diseaseIntrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylationMolecular mechanisms underlying β-adrenergic receptor-mediated cross-talk between sympathetic neurons and immune cellsEndogenous G protein-coupled receptor kinase 6 Regulates M3 muscarinic acetylcholine receptor phosphorylation and desensitization in human SH-SY5Y neuroblastoma cellsProtein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted systemA Ser/Thr cluster within the C-terminal domain of the rat prostaglandin receptor EP3alpha is essential for agonist-induced phosphorylation, desensitization and internalizationAltered beta-2 adrenergic receptor gene expression in human clinical hypertension.Signal transduction by protease-activated receptorsRegulation of Fc∈RI signaling in mast cells by G protein-coupled receptor kinase 2 and its RH domain.Acute and chronic regulation of pituitary receptors for vasopressin and corticotropin releasing hormone.Agonist-selective mechanisms of GPCR desensitizationRetromer terminates the generation of cAMP by internalized PTH receptors.International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors.Oligodeoxynucleotides antisense to mRNA encoding protein kinase A, protein kinase C, and beta-adrenergic receptor kinase reveal distinctive cell-type-specific roles in agonist-induced desensitization.Non-canonical signaling of the PTH receptorPhosphorylation-independent inhibition of parathyroid hormone receptor signaling by G protein-coupled receptor kinasesNoncanonical GPCR signaling arising from a PTH receptor-arrestin-Gβγ complexPhosphorylation of the InaD gene product, a photoreceptor membrane protein required for recovery of visual excitation.The β-Arrestins: Multifunctional Regulators of G Protein-coupled ReceptorsMorphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestinsRapid recycling of beta-adrenergic receptors is dependent on the actin cytoskeleton and myosin Vb.Targeted transgenesis reveals discrete attenuator functions of GRK and PKA in airway beta2-adrenergic receptor physiologic signalingPhysiological and pharmacological implications of beta-arrestin regulation.Protein kinase cross-talk: membrane targeting of the beta-adrenergic receptor kinase by protein kinase C.Endocytosis and signaling: cell logistics shape the eukaryotic cell plan.Roles of proteolysis in regulation of GPCR function.Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79.Phosphoproteomic analysis reveals compensatory effects in the piriform cortex of VX nerve agent exposed rats.Effects of combined progesterone and 17β-estradiol treatment on the transcriptome of cultured human myometrial smooth muscle cells.Heterologous desensitization of cardiac β-adrenergic signal via hormone-induced βAR/arrestin/PDE4 complexes.GPCR desensitization: Acute and prolonged phases.Protein kinase C as a tumor suppressor.Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor.Identification of a Ser/Thr cluster in the C-terminal domain of the human prostaglandin receptor EP4 that is essential for agonist-induced beta-arrestin1 recruitment but differs from the apparent principal phosphorylation site.The palmitoylation state of the beta(2)-adrenergic receptor regulates the synergistic action of cyclic AMP-dependent protein kinase and beta-adrenergic receptor kinase involved in its phosphorylation and desensitization.Phosphorylation uncouples the gastrin-releasing peptide receptor from G(q).Mutation of individual serine residues in the C-terminal tail of the lutropin/choriogonadotropin receptor reveal distinct structural requirements for agonist-induced uncoupling and agonist-induced internalization.Mechanism of quenching of phototransduction. Binding competition between arrestin and transducin for phosphorhodopsin.Phosducin inhibits receptor phosphorylation by the beta-adrenergic receptor kinase in a PKA-regulated manner.
P2860
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P2860
Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms
description
1992 nî lūn-bûn
@nan
1992 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի մարտին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Desensitization of the isolate ...... distinct molecular mechanisms
@ast
Desensitization of the isolate ...... distinct molecular mechanisms
@en
Desensitization of the isolate ...... distinct molecular mechanisms
@nl
type
label
Desensitization of the isolate ...... distinct molecular mechanisms
@ast
Desensitization of the isolate ...... distinct molecular mechanisms
@en
Desensitization of the isolate ...... distinct molecular mechanisms
@nl
prefLabel
Desensitization of the isolate ...... distinct molecular mechanisms
@ast
Desensitization of the isolate ...... distinct molecular mechanisms
@en
Desensitization of the isolate ...... distinct molecular mechanisms
@nl
P2093
P356
P1433
P1476
Desensitization of the isolate ...... distinct molecular mechanisms
@en
P2093
P304
P356
10.1021/BI00127A021
P407
P577
1992-03-31T00:00:00Z