Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective - Wikidata - wikimedia - TriplyDB

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

http://www.wikidata.org/entity/Q28185660

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The prion hypothesis in Parkinson's disease: Braak to the future Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration.p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation The Guanine nucleotide exchange factor kalirin-7 is a novel synphilin-1 interacting protein and modifies synphilin-1 aggregate transport and formation Prion Aggregates Are Recruited to the Insoluble Protein Deposit (IPOD) via Myosin 2-Based Vesicular Transport Recruitment of the oncoprotein v-ErbA to aggresomes.Polarised asymmetric inheritance of accumulated protein damage in higher eukaryotes Identification of Cellular Proteome Modifications in Response to West Nile Virus Infection Autophagy fights disease through cellular self-digestion 14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes Immunomodulators as Therapeutic Agents in Mitigating the Progression of Parkinson's Disease The parkin-like human homolog of Drosophila ariadne-1 (HHARI) can induce aggresome formation in mammalian cells and is immunologically detectable in Lewy bodies Casein kinase II-mediated phosphorylation regulates alpha-synuclein/synphilin-1 interaction and inclusion body formation Modulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanisms Aggresome formation and neurodegenerative diseases: therapeutic implications Seipinopathy: a novel endoplasmic reticulum stress-associated disease Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease α-Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinson's disease Biochemical assessment of precuneus and posterior cingulate gyrus in the context of brain aging and Alzheimer's disease RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils.Implications of protein structure instability: from physiological to pathological secondary structure.Ubiquitination is involved in secondary growth, not initial formation of polyglutamine protein aggregates in C. elegans.Proteasome failure promotes positioning of lysosomes around the aggresome via local block of microtubule-dependent transport.Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation.Insights into the effects of alpha-synuclein expression and proteasome inhibition on glutathione metabolism through a dynamic in silico model of Parkinson's disease: validation by cell culture data.Focal distortion of the nuclear envelope by huntingtin aggregates revealed by lamin immunostaining Aggresome-forming TTRAP mediates pro-apoptotic properties of Parkinson's disease-associated DJ-1 missense mutations.Virus-Induced Chaperone-Enriched (VICE) domains function as nuclear protein quality control centers during HSV-1 infection Synphilin-1 enhances α-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner Aggresome formation is regulated by RanBPM through an interaction with HDAC6 Herpes simplex virus reorganizes the cellular DNA repair and protein quality control machinery.Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications Protein quality control during erythropoiesis and hemoglobin synthesis Congenital cataract causing mutants of αA-crystallin/sHSP form aggregates and aggresomes degraded through ubiquitin-proteasome pathway.Hsp70 and its molecular role in nervous system diseases Disentangling the relationship between lewy bodies and nigral neuronal loss in Parkinson's disease.p62/sequestosome 1 regulates aggresome formation of pathogenic ataxin-3 with expanded polyglutamine

P2860

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P2860

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

http://www.wikidata.org/entity/Q28185660

description

2004 nî lūn-bûn

@nan

2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2004年の論文

@ja

2004年論文

@yue

2004年論文

@zh-hant

2004年論文

@zh-hk

2004年論文

@zh-mo

2004年論文

@zh-tw

2004年论文

@wuu

name

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

@ast

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

@en

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

@nl

type

label

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

@ast

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

@en

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

@nl

prefLabel

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

@ast

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

@en

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

@nl

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Journal of Biological Chemistry

P1476

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

@en

P2093

Eunsung Junn

http://www.w3.org/2001/XMLSchema#string

Gwang Lee

http://www.w3.org/2001/XMLSchema#string

M Maral Mouradian

http://www.w3.org/2001/XMLSchema#string

Mikiei Tanaka

http://www.w3.org/2001/XMLSchema#string

Takeshi Iwatsubo

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Yong Man Kim

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4625-31

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scholarly article

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3254982

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10.1074/JBC.M310994200

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6

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279

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2004-02-06T00:00:00Z

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14627698

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