Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells
about
Polyubiquitylation of AMF requires cooperation between the gp78 and TRIM25 ubiquitin ligasesHuman HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulumRecruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membraneThe activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding siteUbiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3Ubiquitin ligases in cholesterol metabolismThe delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiologyInositol 1,4,5-trisphosphate receptor ubiquitination is mediated by mammalian Ubc7, a component of the endoplasmic reticulum-associated degradation pathway, and is inhibited by chelation of intracellular Zn2+The role of a novel p97/valosin-containing protein-interacting motif of gp78 in endoplasmic reticulum-associated degradationStringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-LS substrates.A role for KAI1 in promotion of cell proliferation and mammary gland hyperplasia by the gp78 ubiquitin ligase.Apolipoprotein B100 quality control and the regulation of hepatic very low density lipoprotein secretion.Targeting of gp78 for ubiquitin-mediated proteasomal degradation by Hrd1: cross-talk between E3s in the endoplasmic reticulum.The Unfolded Protein Response, Degradation from Endoplasmic Reticulum and CancerProtein disulfide isomerases contribute differentially to the endoplasmic reticulum-associated degradation of apolipoprotein B and other substratesDerlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid dropletsAberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase.A foldable CFTR{Delta}F508 biogenic intermediate accumulates upon inhibition of the Hsc70-CHIP E3 ubiquitin ligase.Monogenic hypocholesterolaemic lipid disorders and apolipoprotein B metabolism.The protective and destructive roles played by molecular chaperones during ERAD (endoplasmic-reticulum-associated degradation).Silencing of Small Valosin-containing Protein-interacting Protein (SVIP) Reduces Very Low Density Lipoprotein (VLDL) Secretion from Rat Hepatocytes by Disrupting Its Endoplasmic Reticulum (ER)-to-Golgi TraffickingAutocrine motility factor receptor: a clinical review.The many intersecting pathways underlying apolipoprotein B secretion and degradationThe ever-expanding role of degradation in the regulation of apolipoprotein B metabolism.Glycosyltransferase GLT8D2 positively regulates ApoB100 protein expression in hepatocytes.Regulation of mitochondrial antiviral signaling (MAVS) expression and signaling by the mitochondria-associated endoplasmic reticulum membrane (MAM) protein Gp78.Androgen Mediated Regulation of Endoplasmic Reticulum-Associated Degradation and its Effects on Prostate Cancer.Life and death of a BiP substrateThe effect and mechanism of tamoxifen-induced hepatocyte steatosis in vitro.Apolipoprotein B100 biogenesis: a complex array of intracellular mechanisms regulating folding, stability, and lipoprotein assembly.Gut-liver interaction in triglyceride-rich lipoprotein metabolism.Specificity and regulation of the endoplasmic reticulum-associated degradation machinery.The role and therapeutic implications of RING-finger E3 ubiquitin ligases in hepatocellular carcinoma.The Role of the Transmembrane RING Finger Proteins in Cellular and Organelle FunctionAcetylation of N-terminus and two internal amino acids is dispensable for degradation of a protein that aberrantly engages the endoplasmic reticulum translocon.Deacetylation of HSPA5 by HDAC6 leads to GP78-mediated HSPA5 ubiquitination at K447 and suppresses metastasis of breast cancer.The evolving role of ubiquitin modification in endoplasmic reticulum-associated degradation.Membrane Protein Quantity Control at the Endoplasmic Reticulum.Regulation of diacylglycerol acyltransferase 2 protein stability by gp78-associated endoplasmic-reticulum-associated degradation.Regulation of mitophagy by the Gp78 E3 ubiquitin ligase.
P2860
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P2860
Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells
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2003 nî lūn-bûn
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2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
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2003年の論文
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2003年論文
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2003年論文
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2003年論文
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2003年論文
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2003年論文
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2003年论文
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name
Overexpression of the tumor au ...... ipoprotein B100 in HepG2 cells
@ast
Overexpression of the tumor au ...... ipoprotein B100 in HepG2 cells
@en
Overexpression of the tumor au ...... ipoprotein B100 in HepG2 cells
@nl
type
label
Overexpression of the tumor au ...... ipoprotein B100 in HepG2 cells
@ast
Overexpression of the tumor au ...... ipoprotein B100 in HepG2 cells
@en
Overexpression of the tumor au ...... ipoprotein B100 in HepG2 cells
@nl
prefLabel
Overexpression of the tumor au ...... ipoprotein B100 in HepG2 cells
@ast
Overexpression of the tumor au ...... ipoprotein B100 in HepG2 cells
@en
Overexpression of the tumor au ...... ipoprotein B100 in HepG2 cells
@nl
P2093
P2860
P356
P1476
Overexpression of the tumor au ...... ipoprotein B100 in HepG2 cells
@en
P2093
Allan M Weissman
Henry N Ginsberg
Jun-Shan Liang
Junji Yamaguchi
Shengyun Fang
P2860
P304
P356
10.1074/JBC.M302683200
P407
P577
2003-06-27T00:00:00Z